Comment · Mon, March 28, 2016
Which universities is Ceretropic partnering with and what research is being pursued?
Original post in this thread
narlsnarly · 4 points
Which universities is Ceretropic partnering with and what research is being pursued?
What they were answering
rmcfar11 · 1 points
=)
Quick question regarding peptides like Semax/Selank and/or derivatives, have you ever looked into trying it with a D-Linked terminal amino acid? I know that D-AA are far more expensive than the typical L form, but it has been verified in studies that a terminal AA with a D configuration increases the peptides resistance to being metabolized. I'm betting you're aware of this, though?
No, I don't believe it's been experimented with Semax/Selank yet, but it has been done with various other ACTH analogs/partial chains.
u/MisterYouAreSoDumb
The issue with using, in the case of Semax, a D-proline, is that we do not know how that will affect the binding affinities of that side of the peptide. So while it would be less likely to metabolize from that side, since endogenous enzymes are meant for the L isomer, it's also going to affect the receptors that D-proline would bind to. The Proline-Glycine-Proline end of the peptide is the BDNF/Nootropic end. So modifying the form of the C-terminal amino acid could affect how well it works.