Which universities is Ceretropic partnering with and what research is being pursued?

Comment · Mon, March 21, 2016 · 2 pts

We are working with the Barrett Honors College at ASU, offering part time lab positions to honors students. This gives them lab credit, and a place to learn new things, while giving us access to good people. We are spons

Comment · Mon, March 28, 2016 · 1 pts

Awesome!

Comment · Mon, March 28, 2016 · 1 pts

The issue with using, in the case of Semax, a D-proline, is that we do not know how that will affect the binding affinities of that side of the peptide. So while it would be less likely to metabolize from that side, sinc

Comment · Tue, March 29, 2016 · 1 pts

Semax's C-terminus ends with a proline. It's N-terminus is methionine. The standard method to protect the N-terminus is acetylation. No need to change the isomer of the methionine. If you find the studies where they modi

Comment · Tue, March 29, 2016 · 1 pts

Boom baby: [Behaviourably active ACTH analogues](https://mega.nz/#!AQxCRSjb!cVvrKL8IrkJG3WJMesvhSInI2Um_8NYkEL8RuIWsd00) They replaced the phenylalanine in the sequence with its D-isomer, not the methionine on the N-ter

Comment · Wed, April 13, 2016 · 1 pts

Can you upload that paper for me, or give me the DOI? I would love to read it. Prolyl endopeptidase is certainly the enzyme that cleaves off the C-terminal end of Semax. That is what the amidation is protecting from. Th

Comment · Wed, April 13, 2016 · 1 pts

I could see why some would find the stimulation more pronounced with the subcutaneous admin, and the mental "nootropic" effect more pronounced with nasal admin. That could be why some people prefer one route over the oth

Comment · Thu, April 14, 2016 · 1 pts

[The Nootropic and Analgesic Effects of Semax Given via Different Routes](https://mega.nz/#!ZYxEAKzI!6IMF7S07-hyRKID6ZXELNkZk-q9qxFd1U_1wsTgU4Rk) Quoting for others reading: > The nootropic effects of Semax were stu

Comment · Sun, April 17, 2016 · 2 pts

Post them here or PM. Doesn't matter to me. That's arachidonic acid Semax. I have known about that for a while. I even tried a couple synths of it a year or so ago. They were not successful with the bulk arachidonic aci

Comment · Mon, April 18, 2016 · 1 pts

My plan is to circle back around to AA-Semax when I have some more time, and get cash flow steady again. It's doable. I just need to do some more legwork on a custom arachidonic acid synth with the correct chirality. Hav

Comment · Thu, April 21, 2016 · 1 pts

> I'm surprised that it is expensive/difficult as it's a fairly common fatty acid? Yeah, I was surprised too. The bulk AA that we got just would not work in the solid phase peptide synthesis. Not sure why. >What about

Comment · Fri, April 22, 2016 · 1 pts

Not just that, but it increases the affinity of Semax to its binding sites in the brain. So it's not just about BBB permeability with arachidonic acid.

Comment · Fri, April 22, 2016 · 1 pts

Yeah, it's getting the arachidonic acid synthesized in large enough amounts, for a cheap enough price, in the form that will work for solid phase peptide synthesis. I have not been able to figure out why the peptide lab

Comment · Fri, April 22, 2016 · 1 pts

>The production synth AA wasn't made by the same lab correct? Correct, it was a different lab. However, I had the peptide lab test the AA we got, and they said it was correct. So I am not sure. He might have some ideas

Comment · Sat, April 23, 2016 · 1 pts

No, that was just me using the wrong term. I should have said conformation. The peptide lab we were working with seemed to think it could be made in different conformations, and that is why it was not working in the soli

Comment · Mon, April 25, 2016 · 1 pts

Yes, I believe solid phase synthesis of AA-Semax involves SN2 reactions, as they are replacing the N-acetyl group with arachidonic acid.

Comment · Mon, April 25, 2016 · 1 pts

Ok, cool. Let me know what he says.