Comment · Wed, February 18, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
DudeWhoRejectsLabels · 1 points
I bet you Pfizer is screwing shit up, and not telling anyone.
You're not going to get me to bet against that at any odds.
Humans are going to mess up.
Very true. Hopefully they find out this was a one time shipping error and you caught the only mistake.
u/MisterYouAreSoDumb · Ceretropic
Hopefully they find out this was a one time shipping error and you caught the only mistake.
I doubt it. My hopes for a worry-free supply chain are probably never going to be realized. I am just going to have to put processes in place so that I am not the one personally worrying about it. Haha.
We are going to bring as much as we can in house, as soon as we can. First is a full testing lab with GC/MS and NMR, then comes the peptide lab, along with qualified staff to operate it. We'll see if it makes sense to bring powder synths in house at some point too.