Comment · Wed, December 7, 2016 · Ceretropic & Nootropics Depot
IT'S HERE!!!! P21
What they were answering
janowski_d · 6 points
u/MisterYouAreSoDumb any chance you can describe P21 and Orexin-A and how they affect you?
I know basics of them, but still info is quite spare. Is Orexin-a worth trying on top of modafinil? What kind of P21 regime is a good starting point?
Thanks
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Here's the thing, I want to avoid giving my own anecdotes for a bit, to prevent confirmation bias. I don't want people seeing how I react, then convincing themselves they react the same way. I want people to try it themselves, and assess things as objectively as they can.
I will say P21 was developed to be a potent activator of ciliary neurotrophic factor (CNTF). Blocking CNTF completely blocked the neurotrophic effects of Cerebrolysin. So it's postulated that CNTF is the main mechanism behind Cerebrolysin's neurogenetive effects. P21 was developed using epitope mapping, to find the most effective activator of CNTF. So while the sequence is not found in Cerebrolysin, it's a more potent activator of CNTF than the peptides that are in Cerebrolysin.
Orexin-A is pretty cool. Again, I'll leave my anecdotes out of it for now. People with narcolepsy are deficient in Orexin-A, and research has shown that lower levels leads to sleepiness. In addition, orexin receptor antagonists are being investigated for insomnia. So the orexin receptor seems to play a key role in wakefulness.