Comment · Fri, February 6, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
NotSoShyAlbatross · 1 points
Daily:
Creatine 1 tsp
Piracetam 1/2 Tsp
NALT 350mg
ALCAR 500mg
L-Theanine 75mg
butter MCT Coffee
just cycled Noopept back in, 10mg subl 1 hour before I eat, three times a day
2 days a week:
sub in phenylp, front load 250mg redose 100mg early afternoon
Mg glyc every night for my headaches et al, yerba mate or green tea with mint alternately.
I know what I need to do, I know how to do it, I'm a fast learner and a fast reader. The noots help me do more of that per day and I just budget good recharge time.
What I want is something that will help me focus on a task, not get distracted or annoyed at having to do it, and only very mildly reduce useless anxiety. I like the adrenaline of a tight deadline, but I lose patience with ridiculous demands.
Make sense? Too wordy?
u/MisterYouAreSoDumb · Ceretropic
I'd say Semax would be a good candidate. If you usually get anxiety from stimulants, then Selank might be a better option. Some people can get anxious on Semax, while others find it anxiolytic.