Comment · Thu, February 5, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
sprinterglory · 2 points
I second the question. I've been waiting for the nasal-spray versions of N-Acetyl SEMAX to be released, and then I see this one hit, and I'm like whoa--maybe I need to wait a little bit longer to try the next greatest version of SEMAX.
Gotta love Ceretropic--keeps us excited with all these new developments. I really think it's great how they're trying to push us toward progress by trying novel things in the nootropics field.
u/MisterYouAreSoDumb · Ceretropic
Thanks! We've got so many new projects going on. I lose track of them all sometimes. I went a little nuts these past couple months with new substances/projects. I am circling back now to try and weed through which ones will make it to production.