Comment · Thu, February 19, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
DeltruS · 1 points
You know, Semax's effect on anxiety might be due to the immune system.
Selank1, 2 reduces Th1 and increases TH2 while Semax1 increases immune response in general (I think).
Many cytokines such as IL-1 increase anxiety by a ton. Anecdotally, just today I took 800 mg 65% boswellia extract and my anxiety went way down.
u/MisterYouAreSoDumb · Ceretropic
Yeah, it's definitely due to the adrenocorticotropic hormone response and immune modulation. I wonder if someone that gets anxiety with Semax took Anakinra along with it?