Comment · Tue, February 17, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
DudeWhoRejectsLabels · 2 points
Ha, I can imagine. "Bromantane review: I'm not certain there are any effects because existence isn't continuous, it's a collection of instances. Not recommended for public speaking or situations where causality applies."
Hopefully if any consumers already got some of the bad batch, they don't just jump right into 200+ mg or something. Is this a supplier who's been trustworthy in the past? I'm assuming this was a mistake and not a deliberate fake.
u/MisterYouAreSoDumb · Ceretropic
This is a long time trusted supplier, that supplies a lot of the more esoteric substances to many vendors. They were the only ones I had never had issues with, and the only ones I fully trusted. Every other supplier has messed something up. Now every supplier has messed something up.
Nothing surprises me anymore. Humans are going to mess up. That's just a fact. The more I get into everything, the more I realize the incompetence I saw in the telecom and IT industry, is just as rampant in this industry. I bet you Pfizer is screwing shit up, and not telling anyone. We saw the other day with the article about the FDA sweeping fraud evidence under the rug.
I took 100mg of the powder myself, to test it out. I definitely felt stimulated and happy. That is to be expected with DXM, though. It's a mild stimulant and SSRI. Since I am used to taking 60mg for tolerance reversal, the 100mg did not dissociate me.