Comment · Thu, February 5, 2015 · Ceretropic
Olfactory Transfer?? Peptides passing BBB
Original post in this thread
OrphanatorLS · 4 points
From Wikipedia, "The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly.,[11][12]
The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13][14]
Olfactory transfer could theoretic…
What they were answering
dilated_student · 1 points
So no NASEMAX sprays for us anytime soon? :_(
u/MisterYouAreSoDumb · Ceretropic
Those are happening around the 20th of this month. I am just waiting on any more nasal sprays of Semax versions, till I settle on the one that is most effective. I am not even ordering more Amidate vials yet. Once this trail stock runs out, it gone till I decide on what form works the best.