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123 matches · Nicotine
Eurycomax - my (almost 1 year update)
Replying to Warren_sl · I’m very excited to try it, how do your choices of L Reuteri strain compare to say BioGaia Gastrus?
BioGaia Gastrus is using DSM 17938 and ATCC PTA 6475. Those are targeting immune regulation, inflammation, and gastrointestinal infection. The strain we are using is targeting uric acid reduction and metabolic health. So our L. reuteri strain is definitely very different. Yeah, I…
The Breakfast of Champions
Replying to AAAUUUUAUAUAUUAUA · Speaking of restocks, i talked to your customer support before ordering a while back and they said that you wont be restocking your nobiletin powders. Unfortunately my package got …
We are going to be making difficult decisions on slow selling SKUs in the coming year, unfortunately. This is not limited to nobiletin power. We have over 600 SKUs right now, which is insane for a company our size. The slow selling SKUs bog our entire production system down and t…
Anecdotes from people using Tribugen regularly for awhile?
Replying to SpeXtreme · Don't want to be a fearmonger but I think I lost more hair showering than before. Took it for a week 1 to 2 caps a day. My hair is thinned a bit but mixed feelings if I should cont…
Yes, Tribulus increases DHT. https://www.sciencedirect.com/science/article/abs/pii/S0944711307002838
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Replying to wavyeggs · What would be your perceptible benefits of Poria? I feel like it’s slightly cholinergic but I can’t really place anything else. I grabbed all the mushrooms at one point and I feel …
Poria, especially when mixed with lion's mane, has a really nice mood boosting effect. Poria contains contains unique lanostane and seco-lanostane terpenes that are not found in other botanicals. These lanostane terpenes seem to have the ability to act on the Rap1 pathway. https:…
Cognance: waste of money
Replying to sxaxrxmxs · I think OP may have an overlooked small point that there seems to be a greater variability in certain nootropics than other substances. I'm curious if your lab director would feel …
>I'm curious if your lab director would feel the effects of caffeine alcohol or painkillers for example. Yet he doesn't respond to so many nootropics. I am not just talking nootropics. I am talking anything. He doesn't really react to caffeine, either. Not much with alcohol. He h…
Black Seed Oil PAHS concern?
Replying to drop0dead · Hahaha, I 100% agree with you there. I didn't mean on the testing for other people side I meant more so testing to find different compounds in marijuana that could be re added into…
Ohh yeah, that is interesting! We have developed our own comprehensive cannabinoid methods for our NIST proficiency program submission, so we can already see a lot of them. I think maybe it was 18 cannabinoids in our method? I will have to look it up. Volatile terpenes are anothe…
NMN Powder
Replying to Dihexa_Throwaway · Do you think that sublingual ROA for powder would be more effective than oral? If so, how would it compare to the enteric coated capsule?
That depends on the specific compound and dose. For NMN, absolutely not. The dose is too high, and the solubilities and chemical kinetics don't lend themselves to efficient sublingual absorption. The people in this industry making sublingual NMN are using it as a buzzword to tric…
Inflamed Liver from Nootropics
Replying to FW900 · EDIT: This is very unlikely as ND (where OP obtained all his nootropics) tests each batch and provides full transparency of the results. The same cannot be said for most supplement…
We have an ISO certified lab in-house, and test for contaminants in every single batch. We have a UPLC-MS, along with tons of other equipment that we use to test every single batch of material that comes into our facility. Then we also test the finished goods to ensure they are i…
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Replying to bean_plant · Does vaporizing nicotine produce AGEs like smoking does?
Not nearly as much, if any. I'm not sure there is enough data to say none, but certainly a lot less than smoking.
What is the role of pyroglutamic acid in the alcohol defense formula?
Replying to Bierak · after quitting memantine this weekend I felt a blackout less pronounced this time. I only took NAC, 1000 mg Piracetam and 20 mg 1% Huperzine before going out. Wonder this time if …
Huperzine-A does bind to the NMDA receptor. https://pubmed.ncbi.nlm.nih.gov/11516831/ https://pubmed.ncbi.nlm.nih.gov/11920920/ >Have you experimented with pregnanolone? I remember reading that in some people it eliminated the negative effects from smoking (not nicotine). I did s…
Need help about ACE2 pathway, nicotine role, potential nootropic to upregulate the expression of it.
Replying to Livai_BlackLagoon · Gosh thank you for these clear explanations. You could be a very great teacher. So. Basically, ACE2 enzyme "open the body" for Covid to enter, but also make it way less dangerous,…
Thanks! I actually was a teacher for years. On the COVID-19 side, it's hard to speculate regarding ACE2 expression. We know that blocking the spike protein of SARS-CoV-2 from binding to ACE2 is a good thing in the early stages, as it blocks the virus from entering the cells. Howe…
Need help about ACE2 pathway, nicotine role, potential nootropic to upregulate the expression of it.
ACE2 is an enzyme (protein) on the surface of certain cells, not a peptide. Certain peptides can bind to ACE2, but ACE2 itself is not a peptide. Proteins are just big strings of peptides, but a peptide is not a protein just like a rectangle is not a square. Bad analogy, but you g…
Fasoracetam and GABA-B receptors recovery
I know a lot of people say fasoracetam is a GABAb antagonist, but that's actually not true. It's actions are much more complex than that. Essentially Fasoracetam modulates the metabotropic glutamate receptors (mGluRs). The mGluRs are not ionotropic receptors like NMDA/AMPA, and d…
What does /u MisterYouAreSoDumb take?
Replying to dominion_over_self · Is this list ranked according to degree of effect on your personal well-being? The ephedrine, not listed in this post has been so effective in improving concentration in what you …
No, it's not ranked at all. That's the order they came out of my brain in. LOL Ephedrine is great, but I do not take it daily. I try to only use it occasionally these days. I used to take it daily, along with nicotine, and I was a machine then. However, that is not a good habit t…
Ever considered a Passionflower extract?
Replying to Darkhorseman81 · Benzoflavone from *Passiflora incarnata* Linn and Chrysin from *Passiflora Caerulea* Linn, are pretty powerful chemicals. Reverses Nicotine associated infertility, and acts as an a…
Chrysin is one were were looking at, actually. We have been working on a bunch of flavones. Chrysin is 5,7-dihydroxyflavone.
If anti-inflammatory drugs can aggravate COVID-19, would the same be the case for anti-inflammatory foods and supplements?
Replying to takatakatakatak · Is it nicotine itself that upregulates ACE2? Or something about smoking? Concerned vaper.
Not sure. Here is the study on it. [Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCov](https://www.medrxiv.org/content/medrxiv/early/2020/02/17/2020.02.05.20020107.full.pdf) They talk about some conflict…
Panamax vs GS15-4 Experiences?
Replying to bglala · Wouldn't it be dangerous to take Panamax ginseng when you've had to much stimulants? I'm thinking of blood pressure. For example: Today I've taken a dynamax capsule, 2 cups of cof…
No, it would not be dangerous. In fact, many of the ginsenosides are cardioprotective. Schisandra also normalizes blood pressure. So taking PanaMAX should actually help, not hurt. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659571
Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?
Replying to Heinstar · Hmm. So does nicotine become anti-nootropic once you build tolerance(nAChRs up-regulation + desensitisation) to it? Is it only considered a nootropic if you use it very sparingly t…
Nootropic is a wide definition. If it improves an aspect of human cognition, and is generally safe, then the argument could be made that it has nootropic qualities. That doesn't necessarily mean that it doesn't hinder a different aspect of cognition, though. Daily nicotine use ce…
Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?
Replying to lifehole9 · What about nicotine as a nootropic? It's worked wonders for me when used acutely.
I really like nicotine. It's great for focus and stimulation. However, I have never really attempted to measure my recall and recognition of things I have learned while on it in a naive state. It could very well be helping some aspects of my cognition, while also slightly impairi…
Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?
Replying to eliteHaxxxor · So would you say chronic longterm use of nicotine would lead to a poorer memory by desensitizing nicotinic ACh receptors?
Possibly. Even acute nicotine impairs some aspects of memory. [The effects of nicotine upon memory and problem solving performance](https://mega.nz/#!UNpm1Byb!oLj1yNMPJR9qBNe9JoBekIePE7bAAyvVgqVOtO8OXpk) >The results of this experiment provide clear evidence that nicotine impairs…
Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?
Nicotine up-regulates nicotinic ACh receptors, but also desensitizes them. It's more complex than just up/down-regulation. Acutely, caffeine lowers GABAergic neurotransmission. [Inhibitory effect of caffeine on GABA-activated current in acutely isolated rat dorsal root ganglion n…
Can I dilute Ceretropic's memantine solution with PG?
Replying to MyFacelessVoid · I was talking about Nicotine vaping hehe.
Ahh yes, I forgot about that one. Haha
Bacopa Monnieri: The Most Impressive Natural Nootropic?
Replying to AdAstraPer5-HT2Ar · Exercise boosts the fuck out of me much more than caffeine or nicotine so there's that. I don't think that there is anything else in my stack that would counter it. Bacopa's pharma…
I think the most likely explanation is the simple one. Bacopa up-regulates tryptophan hydroxylase, which increases 5-HTP production, which competes with L-DOPA for the aromatic L-amino acid decarboxylase enzyme, which lowers dopamine production over time. Taking L-tyrosine with i…
What gingseng works best: GS15-s, Root Extract or Leaf Extract?
Replying to Lokzo55 · Hey man!! Have you thought about releasing an extremely low dose, slow release nicotine like product??! Not in patch form...
I have, but the FDA's recent increase in regulations surrounding nicotine products makes that a bit of a challenge.
Cordyceps Cs-4 vs Cordyceps militaris, which is better?
Replying to tronatula · Because my before and after taking these substances (nicotine, dmae, fish oil, cdp choline, deer velvet..) my digit span scores was always lower. I also felt uncomfortable when on …
Yeah, depression on stronger choline sources (CDP, GPC, etc) is very common. It's why I always suggest people only add in a choline source if they are getting headaches with racetams. I am the same way. I get depressed on choline, which lasts a few days. I am prone to depression,…