Comment · Thu, August 24, 2017 · Ceretropic & Nootropics Depot
Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?
Original post in this thread
trulybadass · 34 points
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437321/
"The density of cortical benzodiazepine-binding sites associated with GABAA receptors is increased by 65%"
What they were answering
Heinstar · 1 points
Hmm. So does nicotine become anti-nootropic once you build tolerance(nAChRs up-regulation + desensitisation) to it? Is it only considered a nootropic if you use it very sparingly to avoid desensitisation?
I take between 750mcg to 3mg of nicotine lozenges per day. I don't feel the urge to take any more as it just stops providing me with any benefits thereafter. First time I took nicotine, it gave me a major mood and thinking/focus boost. Now, it mostly just gives a slight edge to the dopaminergic stimulation of coffee/modafinil but its no longer effective on its own.
These days, I primary use nicotine to get through late afternoon shifts(5:00PM to 11:00PM) as a waiter. Because for some reason, I tend to become mentally fatigued easily during work and coffee used to help with that but gave me insomnia. (I think the SSRIs is to blame) So I replaced it with nicotine as it doesn't seem to give me insomnia after work and it helps me get through work without feeling exhausted.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Nootropic is a wide definition. If it improves an aspect of human cognition, and is generally safe, then the argument could be made that it has nootropic qualities. That doesn't necessarily mean that it doesn't hinder a different aspect of cognition, though. Daily nicotine use certainly builds tolerance. So long-term regular use is going to have some less than desirable effects. I'd agree there are nootropic effects from acute nicotine supplementation, but that those effects go away upon chronic supplementation.