Comment · Wed, December 3, 2025 · ND Owner
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What they were answering
Visual-Reply-5401 · 1 points
the earlier study on hearing loss in the elderly
Hi, /u/MisterYouAreSoDumb. Would you be able to answer a question I have about this? I’m actually in the process of advocating for a relative of mine with early Alzheimer’s disease, with an interest in experimental but safe treatment options. Naturally this has led me to Erinamax, but I’ve also learned of a 3-year-old comment in which you stated that the extract from the original two Taiwanese studies didn’t contain erinacine A after all according to later testing. Besides that relatively old comment, Erinamax has been portrayed be functionally analogous to the extract used in those studies. https://www.reddit.com/r/NootropicsDepot/comments/xl7biw/comment/irteoxe/
My optimistic assumption is that some sort of error was made three years ago which was later realized. Nonetheless, it would be extremely helpful if you could provide some clarity on this discrepancy, if you so please. At the moment I’m still considering suggesting Erinamax to my relative given the other evidence for Erinacine A and related compounds, but I’m debating whether to start him on 500 mg/day or a more cautious 250 mg/day.
u/MisterYouAreSoDumb · ND Owner
I was wrong in those old comments. We worked with the authors of those papers to solve the issue. Erinacine A was being destroyed in the sample prep process, so we thought there was no erinacine A in there, when it was just being destroyed in the lab process. My former lab director was not catching the issue. His position always was that everyone else is wrong. This isn't great for science, as you need to look critically at your own data first, then look critically at other people's data. This is actually what led to our partnership with the people behind that paper in Taiwan. I just visited their facilities last month, actually!
I just had a call with their chairman and head of strategy last night, in fact. We also had a call with their scientific team earlier in the day. We have a great partnership with them now, and have full collaboration on scientific operations now. We are also publishing multiple papers with those authors. I am reviewing one of them as we speak. That is the facility where Erinamax is made for us. It's literally the most impressive facility I have ever been to in the world. That's saying something from me. We have a pretty damn cool lab. Theirs is better than ours. That pains me to say, but it is true. They have a fantastic team there.
So yeah, we were wrong in our conclusions in the early days, based on limitations with our data we hadn't sussed out yet. The breakdown product of erinacine A is dysphoric, not erinacine A itself. It's also not the only erinacine in there. We are working on erinacine C and S right now, too. My comments on the fruiting body being the most studied are still accurate, though. My general conclusion back then was that people have used the fruiting bodies more, and had studied them more. I still feel that way in regards to depression. I think the hericenes and hericenones are better for that than eriancine A. However, there is no doubting erinacine A is better for nerve growth, and that study clearly shows it prevented early onset Alzheimer's. I would say 1,000mg a day is what you should use. It's very safe, and we have cell culture toxicity studies to show that now. We didn't back then.
Sorry for the confusion! I will edit those old comments of mine so others don't get confused. I have to remember to go back and change things when new data comes up.