Comment · Thu, May 15, 2025 · ND Owner
Sleep Support combined with Tauromag and Magnesium Glycinate
Original post in this thread
shellvin1234 · 3 points
Hey guys,
I have taken Tauromag and Magnesium glycinate before bed and it has been decent for sleep so far. I was considering adding Sleep Support (because of neuroprotective effects) along with the Tauromag and Magnesium glycinate. Is this overkill?
What they were answering
ProperBeat · 2 points
No, that's not the way to put it. To make sure your body can actually absorb the bioactives, you first have to prove your product actually has the bioactives.
If the extracted supplement has specifications of the bioactives and reliable lab papers supporting those specifications, that is enough proof for me.
Simply extracting something doesn't make it bioavailable. You have to look at the structure and solubility of the bioactive itself. What you are looking for is the Lipinski's Rule of Five.
Extraction (breaking chitin) releases bioactives, but their solubility, molecular size, and stability determine if they’re absorbed, agreed.
Lipinski’s rules however ignore active transport mechanisms (e.g., beta-glucans via M-cells) and prodrug activation (e.g., hericenones → NGF in vivo).
this study underscores the efficacy of unprocessed material, such as fruiting bodies, as the preferred form of supplementation for potential consumers of C. militaris.
I had DeepSeek analyse the study and after some back and forth, here’s the conclusion:
The authors base their conclusion on three main observations:
1. Antioxidant Activity
* Unprocessed C. militaris showed higher antioxidant capacity (DPPH/ABTS assays) than methanol-extracted samples. Likely due to heat-sensitive phenolics/enzymes degraded during methanol evaporation.
1. Cordycepin Retention
* Methanol extraction…
u/MisterYouAreSoDumb · ND Owner
Again, AI is not suited to analyzing the data we are talking about, and it misinterprets and hallucinates a lot. You have to have it on a very short leash. We use AI every day, but you have to be VERY careful with the prompts and what data you feed it. That study I linked is only the abstract. I have the full paper. I can't link it here anymore, though. Reddit removes Sci-hub links.
Lipinski’s rules however ignore active transport mechanisms (e.g., beta-glucans via M-cells) and prodrug activation (e.g., hericenones → NGF in vivo).
Yes, that's why I said it is not a hard and fast rule, as there are exceptions. Pharmacokinetics are very complex.
Methanol extraction is not used for supplements. It is inferior to dual water/ethanol methods.
This is silly. Methanol is going to pull a lot more than water/ethanol. It just will. You will have to remove the methanol for it to be consumable by humans, but it is going to more efficiently extract compounds from plant and fungal matrices. We use methanol a lot in our sample preps in the lab because of it.
Ignoring bioavailability:
Unprocessed chitin blocks absorption of intracellular actives (e.g., ≤10% of beta-glucans will be absorbed from raw powder).
This makes no sense, and is not supported by any data. Not sure where it came up with that.
I have not seen any research papers that used erinamax or mention erinamax?
Those two studies are on Erinamax. Those are our partners in Taiwan that make it for us. They sell it in Taiwan under the GK Heripene name. Erinamax is the name we gave it here, because that's just a better name. LOL. We are the exclusive distributors of it in North America. We might actually be distributing it to other brands for use in their products here soon, too.