Nicotinamide Mononucleotide Tablets | 125mg | Enteric Coated VS. Nicotinamide Mononucleotide Capsules | 250mg

Comment · Thu, May 5, 2022 · 2 pts

What dose, and how long do you hold it under your tongue?

Comment · Thu, May 5, 2022 · 2 pts

The coating is methylcellulose. No reason it should cause bloating. It's the same coating on NMN as gotu kola and EGCG. Very weird that the NMN is causing it, but the others are not.

Comment · Thu, May 5, 2022 · 2 pts

Then you are just taking it orally. You can really only absorb 5-10mg sublingually over a 30min period. Also, NMN is too polar to absorb through the mucous membranes in the mouth. You need a LogP of 1-5 for things to wor

Comment · Thu, May 5, 2022 · 4 pts

Likely a psychosomatic reaction, unless there are Slc12a8 transporters in the mouth. I don't think there are, though. Maybe there is something we don't know about NMN transport. It's always possible. However, it won't pa

Comment · Thu, May 5, 2022 · 3 pts

Absolutely! Sometimes what works/doesn't work on paper is different in the real world. If there is some active transport happening in the mouth for NMN, that would be great! We just formulated some sublingual tablets yes

Comment · Thu, May 5, 2022 · 1 pts

You can absolutely crush them up and take them orally. The coating just seals the outside. If you crush it up, that external seal layer is broken and the NMN will absorb normally. There is no way to give an exact compari

Comment · Sat, May 7, 2022 · 2 pts

It is an interesting situation, that's for sure. The chemical properties all point to it not absorbing sublingually, but I am not going to pretend we have completed settled the pharmacokinetic possibilities with NMN. Til

Comment · Sat, May 7, 2022 · 1 pts

Sorry they are not working out for you! I wish I could get more data into people's GI tracts to really understand the variability. Things are so complex! I am going to do some testing on sublingual with NMN, too. It shou

Comment · Thu, May 12, 2022 · 2 pts

That is super weird... So sometimes it causes diarrhea, but other times it stops you from passing waste at all?

Comment · Thu, May 12, 2022 · 2 pts

Yeah, could be the NMN. However, I am not sure why it would have that effect.

Comment · Wed, May 25, 2022 · 3 pts

I can buy some of theirs and test it in the lab. Synthetic NMN is synthetic NMN, though. Unless they were doing some sort of citric acid salt. I don't think they are, though. >When purchasing NMN, there are two issues t

Comment · Wed, May 25, 2022 · 2 pts

I'll check with my lab director on the sample. We may have already bought it from them and run it through the lab. Glad you are getting good effects!