Comment · Sat, May 7, 2022 · ND Owner
Nicotinamide Mononucleotide Tablets | 125mg | Enteric Coated VS. Nicotinamide Mononucleotide Capsules | 250mg
Original post in this thread
Dorky_Gaming_Teach · 4 points
I wanted to know if the lower dose enteric coated equates/is similar to 250mg in powdered capsule form because of better bioavailability and absorption. Any help in this regard would be great! Thanks.
What they were answering
RarageInTheGarage · 2 points
I've tried sublingual NMN in the past and found it surprisingly effective vs. just taking it orally, but I don't understand why. I was leaving 300mg under my tongue for 30min before swallowing. In theory that should be way too much to absorb sublingually in one sitting in general before even considering LogP, but still, it kicked in much faster. I take several other things sublingually and I'm not convinced it's all just placebo, otherwise I'd probably get similar "effects" from those too.
That said, the enteric coated tablets are way more dose-efficient, they just take much longer to absorb. NMN is just too expensive to not consider efficiency to be king, so I can't be bothered to experiment with sublingual NMN more.
It may well be that the NMN powder already degraded to nicotinamide/NR/etc. and that's what was getting absorbed (not that I have looked up the LogP of those) - this was years before you came out with your stable NMN powder. Or maybe there's an unknown salivary protein that binds NMN in a similar vein to transcobalamin I binding B12.
u/MisterYouAreSoDumb · ND Owner
It is an interesting situation, that's for sure. The chemical properties all point to it not absorbing sublingually, but I am not going to pretend we have completed settled the pharmacokinetic possibilities with NMN. Till recently, we didn't even know about the Slc12a8 transporters selectively uptaking NMN, so there absolutely could be something else we have not yet discovered. I'll have to do some testing on it.