Comment · Wed, May 20, 2020
What they were answering
arrialexa · 1 points
ahh tianeptine sulphate, I miss you sweet prince.. I don't suppose that would ever pop up on ND again at some point?
u/MisterYouAreSoDumb
Nope, too risky. I have some other cool shit in the works, though! A natural extract with similar affinities!
Comment · Tue, May 12, 2020 · 4 pts
99% of the time an empty stomach is best. There are exceptions, but you will be fine the majority of the time with an empty stomach.
Comment · Tue, May 12, 2020 · 2 pts
My pleasure!
Comment · Thu, May 14, 2020 · 4 pts
No, that's a myth that fat-soluble things need to be taken with fat to absorb. Coluracetam is also soluble in water, albeit sparingly, and its LogP is less than 5. So it can absorb perfectly fine. The only time that come
Comment · Thu, May 14, 2020 · 3 pts
Depends on the veggie cap and substance. Our normal veggie caps dissolve super quickly in the stomach. We are testing out some coated capsules that stay intact till the intestines, but none of our products have those yet
Comment · Thu, May 14, 2020 · 1 pts
Sulbutiamine has a LogP of less than 5. It's not super water soluble, but it is moderately so. The main issue with sulbutiamine is P-glycoprotein. So similar to curcumin.
Comment · Fri, May 15, 2020 · 4 pts
Yes, it rapidly and completely absorbs. Take some pramiracetam and put it in water. See what happens. It's actually MORE water soluble than it is fat soluble. It has both water-soluble and fat-soluble functional groups o
Comment · Mon, May 18, 2020 · 5 pts
That depends on their molecular weight and solubility. If they have a LogP over 5 and a molecular weight over 500 Daltons, then yes. If they have some strange property where they form insoluble crystals in the presence o
Comment · Wed, May 20, 2020 · 2 pts
I meant P-glycoprotein substrate. Sulbutiamine is rapidly and completely absorbed in the GI tract, though. It's affinities toward P-glycoprotein don't seem to affect its GI absorption. However, it could affects it's clea
Comment · Fri, May 22, 2020 · 4 pts
Tianeptine is very useful, when used properly. It just seemed to be that everyone decided to stop using it properly after a while. It's a shame, as it is very useful for many people.
Replying to saladon · I came here after seeing a thread on the Phenibut sub about how some other companies have products that feel stronger than ND's. I wonder how that's possible?
It's not. It's all a bunch of bullshit spewed by people misusing the product, often further spread by our competitors. It's horseshit, plain and simple. I don't get involved on /r/Phenibut because frankly I don't want th
Replying to bejaq · Very interesting, thanks for your take, especially sharing your individual experience! It's kinda strange medicine has focused so much on dependence-forming compounds, although i…
Benzos change the conformation of the GABA receptor complex and fuck with the mesolimbic reward system. That's the real issue. Read this study: [Hooked on benzodiazepines: GABAA receptor subtypes and addiction](https://
Replying to question2552 · Spreading out subreddits is a net negative. Generally, I have NOT noticed that smaller communities like /r/afinil lead to better quality of posts, instead I've notice more difficul…
We've never disallowed *all* modafinil posts. We've always said if there were new and interesting discussions regarding modafinil, or its mechanisms, that we would allow them. People have messaged us when they thought th
You need to start tapering off it now! You are not using it properly, and are going to cause yourself harm. Tianeptine is hard on the liver at those dosages. It is not meant to be taken at 650mg/day. Your usage is irresp
Replying to MystikTrailblazer · Jfc, all those resources spent on stopping emoxypine? I wasn't even aware it's illegal in the US rather messaging has been different, which is moot here anyway. Aside. Thanks for …
Not just emoxypine, but piracetam and the other racetams, tianeptine, adrafinil, SARMs, peptides, etc.
Replying to sirsadalot · Sucks to hear that you have to resort to using kratom. I'm not gonna lie, I'm a little disappointed about that. Have you ever tried bromantane, or other things for dopamine synthes…
It is what it is. The oxycodone after my shoulder surgery is the real culprit in all this. That's what led to the changes in my brain, and I have been dealing with that ever since. I have gone off kratom completely a few