MYASD, taking pills on empty stomach doesn’t matter right?

Comment · Tue, May 12, 2020 · 4 pts

99% of the time an empty stomach is best. There are exceptions, but you will be fine the majority of the time with an empty stomach.

Comment · Thu, May 14, 2020 · 4 pts

No, that's a myth that fat-soluble things need to be taken with fat to absorb. Coluracetam is also soluble in water, albeit sparingly, and its LogP is less than 5. So it can absorb perfectly fine. The only time that come

Comment · Thu, May 14, 2020 · 3 pts

Depends on the veggie cap and substance. Our normal veggie caps dissolve super quickly in the stomach. We are testing out some coated capsules that stay intact till the intestines, but none of our products have those yet

Comment · Thu, May 14, 2020 · 1 pts

Sulbutiamine has a LogP of less than 5. It's not super water soluble, but it is moderately so. The main issue with sulbutiamine is P-glycoprotein. So similar to curcumin.

Comment · Fri, May 15, 2020 · 4 pts

Yes, it rapidly and completely absorbs. Take some pramiracetam and put it in water. See what happens. It's actually MORE water soluble than it is fat soluble. It has both water-soluble and fat-soluble functional groups o

Comment · Mon, May 18, 2020 · 5 pts

That depends on their molecular weight and solubility. If they have a LogP over 5 and a molecular weight over 500 Daltons, then yes. If they have some strange property where they form insoluble crystals in the presence o

Comment · Wed, May 20, 2020 · 2 pts

Nope, too risky. I have some other cool shit in the works, though! A natural extract with similar affinities!

Comment · Wed, May 20, 2020 · 2 pts

I meant P-glycoprotein substrate. Sulbutiamine is rapidly and completely absorbed in the GI tract, though. It's affinities toward P-glycoprotein don't seem to affect its GI absorption. However, it could affects it's clea

Comment · Fri, May 22, 2020 · 4 pts

Tianeptine is very useful, when used properly. It just seemed to be that everyone decided to stop using it properly after a while. It's a shame, as it is very useful for many people.