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Comment · Thu, December 8, 2016 · Ceretropic & Nootropics Depot

IT'S HERE!!!! P21

What they were answering

srubek · 19 points

a peptide similar to cerebrolysin.

increases cognitive performance.

edit::~~check the wiki~~NEVERMIND ... ~~underconstruction~~

edit: There is no wiki for this P21. It's an N-acetylated peptide with the amino sequence DGGL, which is aspartate-glycine-glycine-leucine, with an adamantal-glycine moiety capping the C-terminus [to make it like a sturdy and last longer than otherwise, in laymen's]. It's a very potent activator of CNTF, which is ciliary neurotrophic factor.

MYASD:

I will say P21 was developed to be a potent activator of ciliary neurotrophic factor (CNTF). Blocking CNTF completely blocked the neurotrophic effects of Cerebrolysin. So it's postulated that CNTF is the main mechanism behind Cerebrolysin's neurogenetive effects. P21 was developed using epitope mapping, to find the most effective activator of CNTF. So while the sequence is not found in Cerebrolysin, it's a more potent activator of CNTF than the peptides that are in Cerebrolysin.

CNTF is believed to operate like leptin, but by a non-leptin pathway. Like BDNF, it is a neurotrophic factor, and may stimulate nerve cells to survive

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

That's the wrong P21 srubek!

Other MYASD lines in this threadshowing 40 of 62

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Commentr/NootropicsFeb 18, 2015

Anyone experimented with THT's CNTF fragment 147-150?

No!!!! You can't just say, "Ohh, the active sequence in P21 is DGGL, so let's just sell powdered DGGL!" Pharmacodynamics do not work like that! That would be like saying, "Ohh dopamine is good. Let's sell powdered dopami

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Commentr/NootropicsAug 14, 2014

[High Risk] Has anybody tried P21 yet? It's supposed to be a better version of Cerebrolysin.

Replying to FW900 · Probably safer than Cerebrolysin. No concerns over prions, less risk injecting it subcutaneously vs IM or IV, not loaded with vitamins. This would be perfect to have as a spray bo

Damn guys, I just put it up on the site last night. There is already a post about it? Haha. I am only on my second dose of it. It's very hard to convert the rat dosages in the study to human dosages, because they never

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Commentr/NootropicsMar 8, 2015

Cerebrolysin vs p21.. anyone tried both can comment on difference in effectiveness?

Replying to Jackolysis · Not really enchanced it's more of a see below.

It was enchanted by a woodland fairy. No, it was based off the mechanism of Cerebrolysin. They found out CNTF mediated the neurogenetive effects of Cerebrolysin, then used epitope mapping to find the most potent sequenc

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Commentr/NootropicsAug 20, 2015

Anyone else interested in P21 nasal spray from Ceretropic?

Replying to roybo · Is there any research on p21? The search term "p21" gets over 31k hits on pubmed. The p21 page on wikipedia refers to some massive protein that has something to do with cancer. Ca

You are looking at the wrong P21. There are two compounds commonly referred to as P21.

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Commentr/NootropicsDec 19, 2014

Tianeptine abusers- Another reason your misuse may affect responsible consumers

Replying to Synzael · Okay.. It's a lot different. Semax has been shown to modulate the expression of TKRB (and it's a sub sequence of ACTH) and P21 is based off of cerebrolysin. Mephedrone is based off

What you talking about, Willis? This sub was here long before I came around. I may have gotten interested in neurochemistry because of MDMA and depression. However, this sub did not spawn from that. But your argument st

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Commentr/NootropicsNov 17, 2014

P21 - 5 day review

I always take Semax with P21, to counter the slight tired feeling it can give. I wonder what peptide in Cerebrolysin is leading to the attention effects you are describing? There are only a few ones in high enough concen

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