Comment · Fri, January 23, 2015 · Ceretropic
Low dose DXM as a nootropic?
Original post in this thread
Sayitaintsoooooooo · 4 points
I've been wondering about this for a while. I understand there are benefits and drawbacks to frequent DXM use including potential language issues and derealization. I've tried low dose before but not over an extended period of time but I did notice a large boost in mood and motivation. DXM is a dopamine reuptake inhibitor as well as a decent anti depressant but isn't very well understood obviously since studies on it are only primarily focused on it's anti-tussive properties.
Does anyone have any thoughts/experience with DXM as a noot?
What they were answering
[deleted] · 4 points
[deleted]
u/MisterYouAreSoDumb · Ceretropic
There is, but is has not been proven to happen with DXM. There was the famous Olney's legion study, which has since been proven to not happen with DXM.
Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain
This[1] person took chronic low doses and suffer cognitive deterioration.
Notice he states that he was abusing it? That is certainly not advisable. He even states that keeping dosages under 120mg would be advisable for long-term antidepressant use. Even that dosage is too high in my opinion. I would not go over 60mg/day. But I would definitely not cite RoboCodeine7610 as a good source for the safety of DXM. I would bet he was using other things during that 2 years.
So yes, long-term abuse of DXM can cause changes to the brain. It's all about dosages. Low dose DXM is perfectly safe, just like low dose caffeine is perfectly safe. Abusing anything is going to lead to a bad time. Taking 30-60mg for a week is not going to cause any issues whatsoever.