Comment · Fri, January 23, 2015 · Ceretropic
Low dose DXM as a nootropic?
Original post in this thread
Sayitaintsoooooooo · 4 points
I've been wondering about this for a while. I understand there are benefits and drawbacks to frequent DXM use including potential language issues and derealization. I've tried low dose before but not over an extended period of time but I did notice a large boost in mood and motivation. DXM is a dopamine reuptake inhibitor as well as a decent anti depressant but isn't very well understood obviously since studies on it are only primarily focused on it's anti-tussive properties.
Does anyone have any thoughts/experience with DXM as a noot?
What they were answering
[deleted] · 1 points
[deleted]
u/MisterYouAreSoDumb · Ceretropic
The occurrence of Olney's Lesions still has not been proven or disproven in humans.
The lack of evidence of its existence, in the face of repeated attempts, is more telling than stating it has not been unequivocally disproven yet.
have been shown to cause neuronal disturbance and injury in humans at various doses, even low doses and even one dose.
Do you have links to the study showing a single low dose of DXM causing neuronal injury?
Also, you cannot dispute that there would be alterations with respect to synaptic plasticity and the resultant detrimental effect to memory in the hippocampus, as well as spatial memory.
Many things alter synaptic plasticity. That does not mean they are neurotoxic. NMDA antagonists can certainly be detrimental to memory, in a dose-dependent manner. Nobody is arguing against that.
[D. Cognitive deterioration from long-term abuse of dextromethorphan: a case report Psychiatry Neurosci.] has shown that there is long term cognitive deterioration due to DXM.
Again, abuse.
Also, funny enough, the user said he used a low dose chronically and he defined abusing it as this. I believe this is what the topic was about.
I think the people on drugs-forum define low dose a little differently than other people. He even mentions 120mg as the cutoff, which is too high.
So yes, there are risks with DXM. However, making blanket statements that it is neurotoxic, and has no cognitive use, is not right. I do not think people should be using it daily for years, just like I do not think people should be using it for regular dissociative trips. However, it can be a useful tool for short durations in the correct dosage.