Low dose DXM as a nootropic?

Comment · Fri, January 23, 2015 · 7 pts

I've used low dose DXM a ton. It is a very useful substance. The dopamine, serotonin, and Sigma-1 effects provide rapid mood and motivation boosts. Also, the NMDA antagonism provides a quick tolerance reversal to stimula

Comment · Fri, January 23, 2015 · 3 pts

30-60mg daily for a week. I would not mix SSRIs. So I would not feel comfortable saying DXM and escitalopram together would be safe.

Comment · Fri, January 23, 2015 · 3 pts

There is, but is has not been proven to happen with DXM. There was the famous Olney's legion study, which has since been proven to not happen with DXM. [Oral administration of dextromethorphan does not produce neuronal

Comment · Fri, January 23, 2015 · 1 pts

It's pretty funny seeing all the hate for DXM here, but also seeing people down-vote those stating Amphetamine can be neurotoxic, or people perfectly happy speaking about long-term Memantine usage. Everything has it's ri

Comment · Fri, January 23, 2015 · 1 pts

> The occurrence of Olney's Lesions still has not been proven or disproven in humans. The lack of evidence of its existence, in the face of repeated attempts, is more telling than stating it has not been unequivocally

Comment · Sat, January 24, 2015 · 2 pts

Rapid antidepressant and motivation effects. Also, after you complete the cycle, you will notice your tolerance to things like stimulants or opioids has been reduced. It works faster than Memantine for this.

Comment · Sat, January 24, 2015 · 2 pts

Yeah. The serotonin system is very finicky. Mixing two SSRIs, or SSRIs and MAOIs, is always risky.

Comment · Mon, January 26, 2015 · 1 pts

Time is still the crucial factor to get tolerance to reverse. There is no way around that. A single dose of anything is not going to affect tolerance in any meaningful amounts, no matter the dosage. Plus, there is more l

Comment · Wed, January 28, 2015 · 3 pts

I've never really thought about it. I'm still on my own journey. Perhaps when I feel I have really gotten somewhere, I might consider it.

Comment · Wed, January 28, 2015 · 1 pts

No, it gives other effects that are nice. It seems to elevate mood for weeks following use. It might be due to the Sigma-1 agonism. I doubt it is the SRI activities, as I do not find the same effect with other SRIs. Howe