Skip to content

Comment · Thu, August 22, 2013 · Ceretropic

What happens if you stop?

Original post in this thread

insaneInsult · 13 points

There's been very little research done on nootropics and cognitive enhancers in general, I'm not going to argue if it actually works or if it could all be a placebo. But, since we know so little on the scientific effects of nootropics, what happens when our minds becomes so accustomed to the chemical boost and then we stop taking them? Does the mind lose the ability to think rapidly or even lose the ability to focus on something without the chemical advantage?
I for one do not want to become dependent on a drug that could make me stupid(er) if I stop taking my regular dosage.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

Not many people take as many different nootropics as I do; except for some people on Longecity. I've stopped all nootropic supplementation cold turkey multiple times, and had no issues. In fact, I felt fantastic after stopping. That is one weird effect that I get, and I have not been able to isolate the mechanism yet. I think it has something to do with a rebound ACh interaction.

However, as others have already mentioned, you cannot group all nootropics together. Cessation of racetams is going to lead to different effects than cessation of bacopa or rhodiola. Even different racetams are going to vary. However, you are not going to get "stupider" than you were before. If you were smart about your stack, and balanced the receptor up/down-regulation, then cessation should be pretty uneventful. You are not going to have meth withdrawal symptoms or anything. That is, unless your stack contained meth. Then yes, you would have meth withdrawal symptoms.

Other MYASD lines in this thread

Related in the archive

Commentr/NootropicsMay 10, 2013

what's the safest and most reliable

Safest and most reliable? I'd have to say it would be something like DHA, as boring as that sounds. If you are looking specifically for a racetam, then it's going to differ for everyone. I personally think both oxiraceta

3OxiracetamPramiracetamBacopaRacetams
Commentr/NootropicsMar 25, 2016

Bacopa seems controversial here...

Replying to whoisbambam · bacognize makes me utterly exhausted and useless. ur saying that may be due to reduced dopamine? is there a way to raise dopamine without an increase in receptor density that the

Yeah, the exhausted feeling is because it is lowering dopamine and increasing GABA. You can take something to increase dopamine to counteract it. I would suggest Rhodiola and L-Tyrosine. You could also use Phenylpiraceta

2PiracetamPhenylpiracetamBacopaRacetams
Commentr/NootropicsDec 27, 2014

What hasn't worked for you

Replying to Sigfund · I'm sure I could name plenty you'd recommend, and you must have this question all the time, but what would be your primary suggestion do you think? Racetams have done nothing notic

It depends on what you are look for. Semax, and it's N-Acetyl version, have been the most effective for me personally. The new neuropeptides are pretty cool. However, there are so many other substances out there. Natural

2FasoracetamSemaxSelankNSI-189
Commentr/NootropicsJan 28, 2014

5 days of 3 x 1.6g piracetam use. Still no effect?

Replying to jrhsk8 · Anecdotal evidence seems to indicate it's less subtle than that, but I feel like I would notice it if it really did something. If it is really so unnoticeable, is it even worth it?

To be honest, if you are going into this with the thought that you are going to get rapid and noticeable changes, then you are going to be let down more times that you can count. Nootropics are about finding what works w

2TianeptinePiracetamBacopaAshwagandha
Commentr/NootropicsAug 14, 2013

Energy and IQ - A common mechanism?

Replying to deh707 · Ah, thanks for the insight. I'm considering ashwagandha and ginseng, too. Funny how each category/sub-category of common nootropics have one property or the other (energizing or c

Totally different pathways. However, they are all linked. The energizing effects from racetams are glutamate mediated, where rhiodiola is β-adrenergic. Caffeine is adenosine mediated, which indirectly affects the other s

2AniracetamOxiracetamBacopaAshwagandha
Commentr/StackAdviceDec 29, 2013

Can someone recommend a stack for depression, social anxiety, concentration, motivation?

If you want a single substance to help with depression and anxiety, I would say tianeptine. I am taking it right now. It provides a very nice mood uplift for a couple hours. That's the only bad part is the short half lif

3TianeptineColuracetamModafinilBacopa