Comment · Thu, April 25, 2013
MDMA: The 'Dont Re-dose' advice?
Original post in this thread
KosherDev · 25 points
So this came up in another thread and people suggested I make my way over here for a more specific answer.
We've all heard the general advice of not re-dosing on mdma to minimize any potential harmful after effects. It makes sense but is it the act of just 'taking more' that could cause issues, or is it the actual time separation?
So the example. You take an initial 120mg dose, and then a subsequent 60mg dose an hour or so later for a grand total of 180mg.
Vs.
One initial dose of 180mg.
Are they equally 'bad' or does the subsequent dosage cause more complications than one large initial dose? If so, why?
What they were answering
susquehannock · 2 points
Well, neurotoxicity at doses that low has not been studied, the last time I checked, not even in animals.
Hundreds of millions of people have taken doses that low, regularly, and there is no good epidemiological evidence of actual impairments affecting any statistically significant percentage of the user populations
Presumably you already know their is some reportage of SSRI antidepressants causing bad reactions in a very small percentage of normal users at that dose range.
But, pretty much anybody will tell you, if you are concerned enough about neurotoxicity at these very typical dosage ranges, maybe you shouldn't take it.
Statistically, your chances of anything but a good time is so small as to be nearly unmeasurable, at the doses you describe.
u/MisterYouAreSoDumb
What are you talking about?!? Doses as low as the equivalent of 80mg for a 180lb human have been shown be neurotoxic in rats and primates!
Nobody does the allometric scaling of species when referencing dosages. There are many many studies showing neurotoxicity at normal doses.