Comment · Thu, April 25, 2013
MDMA: The 'Dont Re-dose' advice?
Original post in this thread
KosherDev · 25 points
So this came up in another thread and people suggested I make my way over here for a more specific answer.
We've all heard the general advice of not re-dosing on mdma to minimize any potential harmful after effects. It makes sense but is it the act of just 'taking more' that could cause issues, or is it the actual time separation?
So the example. You take an initial 120mg dose, and then a subsequent 60mg dose an hour or so later for a grand total of 180mg.
Vs.
One initial dose of 180mg.
Are they equally 'bad' or does the subsequent dosage cause more complications than one large initial dose? If so, why?
What they were answering
susquehannock · 1 points
well, from the abstracts there is no way to tell if the described enzyme inhibition has clinically detectable effects. Has work been published based on these that describes any clinical or epidemiological measurements?
people do things that are bad for them all the time. Skiing, for example, drinking alcohol, eating sugar, eating beef, having sex, driving to work, breathing city air, drinking from BPA coated cans.
You can't tell from the two abstracts you posted wether the enzyme inhibition or the plasma concentration of metabolites has a medically significant impact on human quality of life.
I'm not saying it doesn't - but the epidemiology still seems pretty clear.
u/MisterYouAreSoDumb
Ohh, and as far as whether or not it impacts humans life, see my posts here.
http://www.reddit.com/r/DrugNerds/comments/1d1yyf/mdma_the_dont_redose_advice/c9m9dz9
http://www.reddit.com/r/DrugNerds/comments/1d1yyf/mdma_the_dont_redose_advice/c9m9a7l
I take MDMA too, so don't take my comments as trying to discourage people from taking it. However, the risks are there, and should be known to everyone before they make the decision to take it.