Comment · Fri, April 26, 2013
MDMA: The 'Dont Re-dose' advice?
Original post in this thread
KosherDev · 25 points
So this came up in another thread and people suggested I make my way over here for a more specific answer.
We've all heard the general advice of not re-dosing on mdma to minimize any potential harmful after effects. It makes sense but is it the act of just 'taking more' that could cause issues, or is it the actual time separation?
So the example. You take an initial 120mg dose, and then a subsequent 60mg dose an hour or so later for a grand total of 180mg.
Vs.
One initial dose of 180mg.
Are they equally 'bad' or does the subsequent dosage cause more complications than one large initial dose? If so, why?
What they were answering
[deleted] · 1 points
[deleted]
u/MisterYouAreSoDumb
The 2012 Neuroscience article only examines thermoregulatory effects, I'm mainly interested in the link to neurotoxicity.
Thermoregulation is directly related to toxicity, though. The higher the body temps, the more 5-HT system damage at the same dose. A substance that is thermoregulatory is going to indirectly mitigate toxicity.
Quite interesting, although I think we should be very careful with extrapolating results in mutant mice to humans.
That's why I included the primate study. All the studies are pointing to the same thermoregulatory effect being the cause of the mitigation of 5-HT system damage. You can get the same results by keeping the test subjects in cold rooms. The evidence is pretty conclusive from my perspective.
Do you have any papers regarding the antioxidant theory?