Comment · Thu, April 25, 2013
MDMA: The 'Dont Re-dose' advice?
Original post in this thread
KosherDev · 25 points
So this came up in another thread and people suggested I make my way over here for a more specific answer.
We've all heard the general advice of not re-dosing on mdma to minimize any potential harmful after effects. It makes sense but is it the act of just 'taking more' that could cause issues, or is it the actual time separation?
So the example. You take an initial 120mg dose, and then a subsequent 60mg dose an hour or so later for a grand total of 180mg.
Vs.
One initial dose of 180mg.
Are they equally 'bad' or does the subsequent dosage cause more complications than one large initial dose? If so, why?
What they were answering
susquehannock · 1 points
sources would be useful. I was just doing some searches with the keywords "mdma neurotoxicity in human studies" and most of the abstracts in the top twenty were pretty old.
u/MisterYouAreSoDumb
Ok, not literally. It's been a month since I last posted them.
http://www.ncbi.nlm.nih.gov/pubmed/17548754
That study showed significantly lower verbal recognition scores in users that had used a total of 1.5 tablets of ecstasy (median), 3.2 tablets (mean). So that is a statistically significant decrease in humans after a single dose.
http://www.ncbi.nlm.nih.gov/pubmed/18609419
That study showed hippocampal remodeling in a girl that had occasional use of low to moderate dose of MDMA.
http://link.springer.com/article/10.1007/s00213-003-1725-2
That study showed neurotoxicity in doses as low as 2mg/kg x3 in rats.
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=716740
That study showed that a 1mg/kg dose of MDMA altered the expression and processing of amyloid precursor protein, which is implicated in Alzheimer's.
http://www.karger.com/Article/Fulltext/26664
That study showed that neurotoxic doses found in animals fall within typical human doses.