Archive

My experience with 4’-DMA-7,8-DHF

Replying to VicemanPro · I love it, I just hate how fast a tolerance develops for me.

Polygala in the evenings seems to help with that.

Erinamax research

Replying to DoctorBoneMarrow · Thanks! Isn't this another one?: [https://www.sciencedirect.com/science/article/pii/S1756464622002900?via%3Dihub](https://www.sciencedirect.com/science/article/pii/S1756464622002…

Yes, that study is on the same material as Erinamax as well. That was on hearing loss in the elderly. The new paper will be on hearing function in healthy individuals, which is super cool!

Ordering emoxypine

Replying to Ineedpalmtreeliving · Im immunocompromised so definitely immunity, then strength/endurance, cns activation, stress regulation, skin and hair health

I'd keep these: * Microzinc * Reishi * Cordyceps * Tongkat * Epicatechin * Shilajit * ALA (I'd do our OptimALA) * Hesperidin * Bacopa (I'd take our Cognance) * Gotu Kola * Polygala * DLPA * Injuv * White Jelly * Agmatine * Taurine

Ecklonia Cava

Replying to Joshpills · im interested in 7,8-dhf and the 4dma version. I have the 4dma version just arrived, im here for the BDNF boost, like mentioned here. what cycle lengths would you take? wou…

For the 4,-DMA-7,8-DHF, I would do shorter cycles. 5 days on and 2 days off is a good place to start. I would suggest taking polygala at night to up-regulate TrkB.

Ecklonia Cava

Replying to Apothacy · We know that supplements GABA and taurine induce a down regulatory affect on gaba when taken on a constant basis, does the same apply to Gotu? Is it preferred to cycle it to maxim…

Increasing GABA always has the potential to cause GABA receptor down-regulation. That's just the body trying to maintain homeostasis. Increasing BDNF can up-regulate GABA receptors, though. It's always about balance. So this is why building a stack is key. Magnesium pidolate has…

A petition to keep powders

Replying to MrRADicalKMS · I have a note in my phone with companies to avoid, and already had all those but Ultima, Zhou, Double Wood, and Primal Harvest, so thanks for those four! As I said in a comment on …

The people that bought Thorne are actually L Catterton, which is the investment arm of LVMH. That's the massive luxury company that owns Luis Vuitton, Moet and Chandon, Hennessy, Sephora, Tiffany, Bulgari, etc. It's just a very large multinational conglomerate that is focused on…

Nootropics depot shilajit tested by ConsumerLabs

Replying to WhnOctopiMrgeWithTek · I literally wish ND sold food like rice, wheat flour, anything and everything olive oil, blah blah, sardines in a can, frozen ground grass-fed. Please ND. Enter the food supply. F…

LOL

Study: Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury

Replying to adeptus8888 · im already taking OG cistanche 50%, erinamax and Tiger milk. interested in motor function and fine muscle control improvements as a pianist. I've noticed erinamax was particularly …

Andrographis would be one I would look into. [Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion](https://link.springer.com/a…

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Replying to slipperybuddha · >I've taken more things than 99.9% of any human On the subject ... could you provide a rough top 10 candidates for "the most mood promoting things" you've ever taken?

I'll just stick to legal things for this conversation. I find our Tongkat 10% to really keep my mood up. No doubt the testosterone is the reason for that. Polygala is another that is mood boosting for me. /u/Pretty-Chill also really loves polygala. I take our saffron every day fo…

Anecdotes from people using Tribugen regularly for awhile?

Replying to TheHealthspanMethod · For Sure. Not intending to dismiss it. It's interesting to see how different people react. I took it again this morning with Polygala and DLPA about an hour before the gym and the …

That's cool! I will have to combine it with polygala and DLPA to see if I notice a synergy as well.

Anecdotes from people using Tribugen regularly for awhile?

Replying to TheHealthspanMethod · I've taken it 5 times 2 capsules each time. I'm a bit surprised as for me it was over-hyped as being so stimulating. I find it pretty chill (no pun intended). So far i've been real…

I think the reason Tribulus has had a controversial reputation over the years is because a lot of people react oppositely to MAOIs. Some people get stimulated, while others don't, or get a calming effect. Both myself, /u/Pretty-Chill, and our lab director get strong stimulation f…

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Replying to usrnmz · Man you guys are really working on cool stuff these days. Sounds like time for a blog post on isoliquiritigenin haha! Some more questions if you don't mind! 1. What are your fav…

1) I like to pair it with GABA, Baikal skullcap, and Sibelius sage. 2) I notice it for 3-5 hours. 3) I do think it has the potential for potentiating stronger stimulants, but it also has a calming effect with the GABA affinities. It's hard to say without trying the specific combi…

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Replying to OneMillionAltAccts · Nothing else has given me that side effect (or really any negative/neutral side effects other than my sweat started smelling like maple syrup after one fenugreek capsule). I could …

Damn, maple syrup after one capsule?!? That's the first I have heard of that! Another guy got it, but after taking a bunch of capsules regularly. Are you talking about our fenugreek capsules? >I could be wrong about what supplements hit which mechanisms, but off the top of my hea…

⚠️ NEW PRODUCTS ALERT | Erinamax Lion's Mane Mycelium Tablets & Isoliquiritigenin Tablets⚠️

Replying to usrnmz · Awesome! Any experience report on the Isoliquiritigenin? It sounds like a really cool one! How do the different mechanisms compare in strength? Is it mainly GABA? Or quite balanc…

Emiel talked about it on this other comment. https://www.reddit.com/r/NootropicsDepot/comments/15b7p3g/question_about_the_new_licorice_extract/jtoyydo/ I've actually used isoliquiritigenin regularly for a very long time. I've had the raw material of it for over a year. It just to…

Life ruined from permanent sexual dysfunction from antidepressants. Help!!

Replying to Dyingalchemist · Astragalus as well. Does ND have anything else that would increase GDNF?

Yeah, our astragaloside IV would be good. Pomella might be another. https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03298-y Then the vitexin in our Vignatex would hit VEGF. https://www.spandidos-publications.com/etm/15/3/3117 So if you take androgr…

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Replying to Mcgrufer · u/MisterYouAreSoDumb and u/Pretty-Chill, what have been your experiences so far with Tiger Milk Mushroom? Given its rarity, there is little knowledge on this one. Additionally, cou…

The most immediate effect I notice is an improvement in breathing and a reduction in inflammation. It's pretty noticeable. There is some mild stimulation, and a cognitive/mood effect that is hard to put your finger on. It's unique because it is hitting TrkA. I am used to things h…

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Replying to IncreasinglyTrippy · Exciting! As usual, hit us with your beta testing experience ND.... Edit: oh and would tiger milk potentially have the save downsides that lions mane have for some people, or woul…

It's completely different than lion's mane. It works through TrkA. 7,8-DHF, lion's mane, and polygala work through TrkB. https://www.nature.com/articles/srep16349 https://pubmed.ncbi.nlm.nih.gov/26853959/ https://www.frontiersin.org/articles/10.3389/fphar.2017.00998/full It's a r…

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Replying to Ratharax · How does the tetrehydromagnolol powder taste? Presumably you could sublingually consume the straight powder if the tablets are subL, eh? I guess like, if you had to rate between po…

The THM tastes pretty neutral. You can certainly use the powder without having to use the tablets. No way is it anywhere close to berberine. That shit is nasty! Yes, the phytosome in Mitidol will make the bioactives more bioavailable. However, you will still get more gingerols/sh…

brain growth factors - anyone tried?

7,8-dihydroxyflavone: https://www.frontiersin.org/articles/10.3389/fphar.2018.00967/full 4,DMA-7,8-DHF: https://europepmc.org/articles/pmc3150605?pdf=render Polygala: https://www.sciencedirect.com/science/article/abs/pii/S0378874120335133 Lion's mane: https://sci-hub.se/10.1615/i…

Cognance with polygala ?

Replying to wtblife · I really don't enjoy matrine, but maybe I just need to try it before bed. I was hoping it was something I could use to help with my chronic pain.

I only use matrine in the evenings as well, if that means anything.

Where We're Going, We Don't Need Roads

Replying to AdvisorHead8533 · Have you tried stacking the new Tickler with Polygala, MYASD ??? I would hypothesize that the NDRI and SNRI properties of Polygala would enhance the spectrum and amplify the mood …

I actually have. I have combined with 7,8-DHF as well. They seem to combine together very well. This one is certainly going to be going in some Natrium stacks later on.

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Replying to Dihexa_Throwaway · Back when I trialed nobiletin, according to Bearable app, I was taking a very basic stack: whey protein (Original Nutrition), magnesium caps (Life Extension) and caffeine (Nespress…

Yeah, white jelly actually increases my mood. However, I do have to be particular about combos. Stacking it with too many other cholinergics can tip the scales. I have been messing around with it, Sibelius sage, and celastrus. I think it is fine with the white jelly and sage, but…

MDMA Supplementation

Replying to xezrsps · I've got mdma induced neurotoxicity and possibly some kind of brain damage related to it are there any supplements that help repair the damage caused by this drug

I would focus on things that increase BDNF, NGF, CNTF, and GDNF. This is what I would suggest. * Andrographis * 4'DMA-7,8-DHF * Polygala * Lion's Mane * Poria Then I would add in some everyday staples that you are likely deficient in, or will correct deficiencies. * Micromag * D3…

Anyone try the saffron yet?

Replying to 7Delusions · Could definitely be. But I think they would also put their hands on other material as well, not only saffron, who knows? I ll make an order soon. It would be my first purchase fro…

Organized crime controls a lot of high value plants around the world, actually. Polygala isn't really stimulating, but you will feel more energized after a few days of taking it.

What helps post alcohol

Replying to townsendc94 · I've been drinking way too much lately. Those three things above you mentioned could possibly mitigate the negatives that occur when stopping or drinking less? Usually, around da…

Yes, that combo will help. Polygala is good, but I wouldn't say for the GABA side of things. You also need to get the dose right. If you are feeling robotic, I would lower the dose or just take it every other day.