Comment · Mon, May 20, 2024 · ND Owner
Study: Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury
Original post in this thread
MisterYouAreSoDumb · 36 points
We found a study on acteoside (verbascoside) from Cistanche that is really interesting!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599386/
​
I'll copy the abstract below, and some highlights I found particularly cool.
​
Chronic spinal cord injury (SCI) is difficult to cure, even by several approaches effective at the acute or subacute phase. We focused on skeletal muscle atrophy as a detrimental factor in chronic SCI and explored drugs that protect against muscle atrophy and activate secretion of axonal growth factors from skeletal muscle. We found that acteoside induced the secretion of axonal growth factors from skeletal muscle cells and proliferation of these cells. Intramuscular injection of acteoside in mice with chronic SCI recovered skeletal muscle weight reduction and motor function impairment. We also identified pyruvate kinase isoform M2 (PKM2) as a secreted factor from skeletal muscle cells, stimulated by acteoside. Extracellular PKM2 enhanced proliferation of skeletal muscle cells and axonal growth in cultured neurons. Further, we showed that PKM2 might cross the blood–brain b…
What they were answering
adeptus8888 · 8 points
im already taking OG cistanche 50%, erinamax and Tiger milk. interested in motor function and fine muscle control improvements as a pianist. I've noticed erinamax was particularly effective for this, although subtle, in that I've become more acutely aware minute movements which contribute to a particular sound or technique on the piano.
are there any other supplements I can look into which might improve this particular niche?
I already have plenty of caffeine (doesn't bother my sleep), bacopa 24, polygala, agmatine sulfate and enough choline from agpc50.
u/MisterYouAreSoDumb · ND Owner