Comment · Tue, July 21, 2020
What they were answering
sirsadalot · 1 points
Hey u/misteryouaresodumb is agmatine the same as polygala for bromantane protein thing?
u/MisterYouAreSoDumb
Come again? Not sure I understand what you are asking.
Comment · Wed, July 22, 2020 · 1 pts
Ohh, I had to click on the link above you. Got it. Was totally confused in my inbox! LOL Yes, agmatine also protects against β-amyloid, but not because of NMDA. https://sci-hub.tw/10.1007/s11033-018-4501-4
Comment · Wed, July 22, 2020 · 2 pts
I don't see any reason you should be worried about the combo, no.
Comment · Wed, July 22, 2020 · 2 pts
I'm happy to help! I love learning, and I love it when other people are interested as well!
Comment · Wed, July 22, 2020 · 1 pts
For up-regulation of dopamine, you are know the common ones. Uridine, Inositol, ALCAR, Sulbutiamine, and Forskolin are the main ones. Cordyceps up-regulates D2 receptors, too. Not sure I have any better alternatives. Exe
Comment · Wed, July 22, 2020 · 1 pts
Yeah, acetyl L-carnitine.
Comment · Wed, July 22, 2020 · 2 pts
Other than L-tyrosine or L-DOPA, not really. You could just try up-regulating tyrosine hydroxylase. It looks like low dose aspirin does that. I will have to research it a bit more. https://link.springer.com/article/10.1
Comment · Thu, July 23, 2020 · 3 pts
Tyrosine hydroxylase is the enzyme that converts tyrosine to L-DOPA. Then L-DOPA gets converted to dopamine by aromatic L-amino acid decarboxylase. So those two enzymes are responsible for how quickly you produce dopamin
Comment · Fri, July 24, 2020 · 2 pts
Dopamine beta-hydroxylase is a different enzyme. That's the one that controls the conversion of dopamine to norepinephrine. [See here](https://upload.wikimedia.org/wikipedia/commons/thumb/a/a3/Dopamine_beta-monooxygena
Comment · Fri, July 24, 2020 · 2 pts
We can look into California poppy. It was not really on our list, but I can add it. We have not yet settled on a standardization or extraction method that we want for skullcap. So we are still in the R&D phase.
Replying to TheOptimizzzer · u/misteryouaresodumb
Oversimplifying it a bit, but: **Reducing tolerance build up from the stimulants.** * Micromag * Agmatine Sulfate * Triacetyluridine * Polygala **Optimizing neurochemistry/dopamine signalling.** * L-tyrosine * Triac
Replying to RSGC9 · Great topic because I wanted to ask you guys at ND about this. I've done alot of research into weight loss maintenance and fitness etc, and there is a huge genetic difference betwe…
Genetics plays a huge role. I am one of those that has to watch what I eat closely or I will gain weight. I can put on weight, both fat and muscles, easily. However, it is much harder for me to lose it. Whereas my friend
Replying to mmajathrowaway · It's going to be the next big thing man. Shh, don't tell anyone but I just placed an order for Tongkat, 7,8-DHF, Pomella and Nigella extracts, watch out!!! Never used any of these…
I am glad to hear you are getting better! That's awesome! Keep on pushing forward. One day it will all be a distant memory, and you will feel like a totally different person.
>Is the ND extract based on BT-11? Sort of. The issue with BT-11 is that they won't share their methods, nor are they interested in selling here in the US. So they are not super helpful with questions. Our polygala was
Replying to sirsadalot · I began using kratom because I thought it was harmless and mostly beneficial. I used small doses of 3 grams 3 times a day for a year straight. This led to an extreme increase in de…
Bromantane is okay. It's not the miracle some people make it out to be. Why are you thinking it is a dopamine synthesis issue? It's likely a down-regulated receptor issue. Uridine can help up-regulate dopamine receptor
Replying to faxmulder · Thanks man for your feedback. Not strictly related, but I have a question about lion’s mane: it seems it could help with lack of focus and mild anxiety. However, what is your opin…
> However, what is your opinion about DHT and/or libido reduction? That's never been reported in a clinical study before. I don't personally have that side effect, nor does anyone in our office. The studies people refer