Comment · Fri, May 6, 2016 · Ceretropic & Nootropics Depot
Cognitive Benefits for Longvida Curcumin?
Original post in this thread
chsam1975 · 9 points
Has anyone that's taken Longvida Curcumin actually noticed any mood/cognitive benefits or does it mainly just help with inflammation? I'm considering adding it to my stack but want to make sure it's worth the cost, which is pretty high compared to many supplements.
edit: I just wanted to add that I'm not looking for suggestions on other supplements or forms of curcumin to take for inflammation. I already take boswellia to reduce inflammation. I'm asking specifically about any cognitive effects from the Longvida extract since it crosses the BBB.
What they were answering
full_silver · 1 points
I agree 100% regarding modafinil. I do not get tolerance for its wakefulness effects (same with caffeine as Examine states). Can you link me the studies that show that free curcumin is responsible for systemic AI instead of the metabolites?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
[Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and
turmerones differentially regulate anti-inflammatory and anti-proliferative responses
through a ROS-independent mechanism](http://carcin.oxfordjournals.org/content/28/8/1765.full.pdf)
You can see in that study that free curcumin itself is the most potent single compound for all improvements, systemic inflammation included. The only other one that comes close is demethoxycurcumin. The only thing more potent than free curcumin is the mixture of all together, which is what all commercial 95% curcumin products are. But free curcumin was the compound that led to the most improvements in inflammation out of all of them. So increasing free curcumin is the most scientifically tested way to lead to its benefits. Meriva says all sorts of things about their stuff increasing demethoxycurcumin a ton. However, you can see by that study that demethoxycurcumin (DMC) is not as potent as free curcumin.
Here is the relevant table. Lower is less inflammation.
Honestly, the best way would be to take some regular 95% curcumin mix with Longvida. Then you get the best of both worlds, along with free curcumin passing the blood brain barrier.
For reference:
Commercially available curcumin used for research and for clinical trials (curcumin mix) contains 77% pure curcumin (Cur), 17% demethoxycurcumin (DMC) and 3% bisdemethoxycurcumin (BDMC).
From Meriva's own site, you can see it leads to mostly increases in demethoxycurcumin (DMC).