Comment · Wed, February 26, 2014 · Ceretropic
Multiple nootropics: Bell-shaped response curve still in effect?
Original post in this thread
Maxwell_V · 5 points
OK, it's the old, well-worn bell-shaped response curve again. Diminished returns when you take more, etc.
But here's what I'm wondering: How does this relate to taking multiple nootropics at the same time?
Let's say you have optimal response to piracetam at 2gm.
And -taken separately- you have best response to phenylpiracetam at 100mg.
Now what happens when you take those dosages together. Do they partially cancel each other out? If not, this would be a good way to boost overall effects.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
It's really very complicated. There is competitive binding affinities you have to consider. Plus, downstream mechanisms that may alter the effects. Not to mention the varying level of responses between different people.
But short answer, yes you can alter the dose/response curve of one nootropic by adding another one in. Take modafinil for example. On its own, 100mg might be work great for you. Add in 100mg caffeine, and you could turn into a jittery mess. Then add 200mg L-theanine into the mix and you might balance things out again.