Comment · Sat, May 7, 2016 · Ceretropic & Nootropics Depot
Cognitive Benefits for Longvida Curcumin?
Original post in this thread
chsam1975 · 9 points
Has anyone that's taken Longvida Curcumin actually noticed any mood/cognitive benefits or does it mainly just help with inflammation? I'm considering adding it to my stack but want to make sure it's worth the cost, which is pretty high compared to many supplements.
edit: I just wanted to add that I'm not looking for suggestions on other supplements or forms of curcumin to take for inflammation. I already take boswellia to reduce inflammation. I'm asking specifically about any cognitive effects from the Longvida extract since it crosses the BBB.
What they were answering
full_silver · 1 points
Looking forward to your comparison, I'll let you know as well. Anyway, off topic, but does longvida inhibit the same enzyme that metabolizes the amphetamine salts in adderall? I think I made a grave mistake, my 15mg XR dose is still going strong 12 hours later and vitamin C doesn't seem to wash it out.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Yes, curcumin inhibits MAO-B, and can intensify amphetamine. Also, curcumin inhibits CYP1A2 (IC50, 40.0 μM), CYP3A4 (IC50, 16.3 μM), CYP2D6 (IC50, 50.3 μM), CYP2C9 (IC50, 4.3 μM) and CYP2B6 (IC50, 24.5 μM), which could slow amphetamine metabolism.