Comment · Wed, July 16, 2014 · Ceretropic
Could acid catalyzed hydrolysis of esters/amides be effecting your nootropic experience?
Original post in this thread
DocDimethyl · 8 points
1) Many nootropics have ester or amide functional groups (Noopept, all of the racetams, any peptide derived molecules, etc.).
2) The stomach has a pH of around 2 (HCl).
3) Esters and amides can be cleaved by a proton catalyzed reaction.
So would the bio availability of nootropics be enhanced by taking simple antacids to try to neutralize the stomach acids?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
That is why we tout the sublingual administration method. This is especially true for things like noopept. Your GI tract is most definitely playing a role in how effective your noots are. Just do a back to back test with oral and sublingual, and you will immediately see a difference. 10mg oral noopept does nothing. However, 10mg sublingually works perfect. Coluracetam is similar too. It is subject to hydrolysis like noooept is.