Comment · Thu, July 17, 2014 · Ceretropic
Could acid catalyzed hydrolysis of esters/amides be effecting your nootropic experience?
Original post in this thread
DocDimethyl · 8 points
1) Many nootropics have ester or amide functional groups (Noopept, all of the racetams, any peptide derived molecules, etc.).
2) The stomach has a pH of around 2 (HCl).
3) Esters and amides can be cleaved by a proton catalyzed reaction.
So would the bio availability of nootropics be enhanced by taking simple antacids to try to neutralize the stomach acids?
What they were answering
scghost · 1 points
Does this apply to adderall too?
u/MisterYouAreSoDumb · Ceretropic
Yes, but for a different reason. Amphetamine absorbs much better if the GI tract has a high pH (low acidity). People usually either take Tums or sodium bicarbonate before their Adderall dose. That helps it to absorb faster and more completely. You can take amphetamine sublingually as well, but most people don't.