Comment · Thu, July 17, 2014 · Ceretropic
Could acid catalyzed hydrolysis of esters/amides be effecting your nootropic experience?
Original post in this thread
DocDimethyl · 8 points
1) Many nootropics have ester or amide functional groups (Noopept, all of the racetams, any peptide derived molecules, etc.).
2) The stomach has a pH of around 2 (HCl).
3) Esters and amides can be cleaved by a proton catalyzed reaction.
So would the bio availability of nootropics be enhanced by taking simple antacids to try to neutralize the stomach acids?
What they were answering
DocDimethyl · 1 points
Some drugs use DMSO (dimethylsulfoxide) as a drug carrying agent for transdermal applications due to its solubility profile affinity for both lipids and aqueous. So maybe another way of adminstration would be to dissolve the compound in this fairly innocuous solvent and massage it into a skin region with nearby blood flows ( ie temples, inner thighs, wrists, etc.)
u/MisterYouAreSoDumb · Ceretropic
DMSO makes you smell like rotten creamed corn. I would not suggest using it.