Comment · Wed, July 24, 2013 · Ceretropic
Noopept Systematic Review
Original post in this thread
[deleted] · 22 points
Wrote up a new post on Noopept for SN.
A few interesting points:
- Not a racetam, but a dipeptide analogue of the racetams
- Effects appear to potentiate over a 28 day period, with little to no tolerance showing
- Has positive cognitive effects and acts as an immuno-corrector
What they were answering
esthers · 2 points
I can't read the whole [5] study linked, but this was from the abstract:
Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, noopept exhibited immunocorrector properties.
So it exhibits immunocorretive properties, but it seems to stimulate the immune system. Isn't there a possibility it would also stimulate a healthy immune system and lead to inflammation?
I'm not saying I know...I am truly unsure. I was hoping someone with more knowledge and access to the full study could shed more light on it.
EDIT: I've been looking into peritoneal macrophages, and it seems the peritoneal cavity is exactly where I was feeling sensitivity and pain when taking sublingual doses of noopept. I don't want to jump to conclusions but this is a strange coincidence, and I wasn't aware of the peritoneal cavity OR the effect of noopept on peritoneal macrophages when I quit taking it due to this side effect.
u/MisterYouAreSoDumb · Ceretropic
Immunopharmacological properties of noopept.pdf
These results are consistent with published data on immunocorrective activities of regulatory peptides. A series of experiments performed by A. A. Mikhailova et al. showed that myelopeptides act as immunocorrectors, in particular, hexapeptide MP-1(Phe-Leu-Gly-Phe-Pro-Thr) restored immune response suppressed by irradiation, antibiotics, cytostatics, while myelopeptide MP-3 stimulated functional activity of macrophages [6,7]. Administration of noopept to NMRI mice selectively increased the titer of antibodies to β-amyloid (25-35) peptide pre-fibrils [12], which is an important factor of the neuroprotective effect of this preparation in neurodegenerative disorders. The efficiency of noopept in experimental ischemic stroke was demonstrated [3]. It is well known that changes in the immune response during cerebral ischemia lead to apoptotic death of lymphocytes and shift the T-helper response towards Th2.
Stroke induces long-lasting depression of the cell-mediated immunity (monocyte deactivation, lymphopenia, Th1/Th2 shift) and promotes inflammation, which leads to aggravation of brain injury and widening of the ischemic area [13,15]. In our experiments, noopept exhibited maximum activity under conditions of CP-induced immunodeficiency and genetically determined low response to SE in C57Bl/6 mice, which also attests to immunocorrective properties of this preparation. Thus, the combination of immunotropic activity and pronounced antiinflammatory properties in noopept suggests the possibility of using this preparation for the treatment of neurodegenerative disorders associated with the development of immunodeficient states caused by age-related disturbances in humoral and cellular immunity, physical and psychoemotional traumas.