Comment · Tue, January 29, 2013 · Ceretropic
Modafinil + Piracetam excitotoxicity?
Original post in this thread
FlyingWhales80 · 25 points
I have heard many accounts of how mixing amphetamines (i.e. adderall) with piracetam is dangerous due to the probability of excitotoxicity, where NMDA receptors are overworked and essentially die.
My question is whether or not there is reason to believe that the same thing could happen between Modafinil (not a traditional stimulant) and Piracetam (or any racetam, for that matter). Modafinil partially has its effects through dopamine and norepinephrine, just like amphetamines, so I'm curious if there is the same risk involved.
What they were answering
[deleted] · 1 points
[deleted]
u/MisterYouAreSoDumb · Ceretropic
All evidence points to them being perfectly safe and neuroprotective.
That is what I said. I cannot find any evidence that it would exacerbate glutamate damage, and apparently neither can you. I can find evidence that they are neuroprotective to glutamate damage, though. So unless you can find any shred of evidence to bolster your case, you have none. Find me one study, just one single study to justify your stance.
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especially because there is such little evidence out there suggesting anything about piracetam and other similar compounds.
I think it is you that is showing your naivety...
Piracetam's effects on the NMDA receptors.
Piracetam stimulates the metabolic glucose pathway.
Changes in the brain biogenic monoamines of rats, induced by piracetam and aniracetam.
Piracetam defines a new binding site for allosteric modulators of the AMPA receptors.
Modulation of AMPA receptors and the action of nootropic drugs.
Aniracetam enhances synaptic excitation by modulating AMPA receptors.
Receptor changes and LTP caused by administration of aniracetam.
Allosteric modulation of AMPA receptors by aniracetam.
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam.
Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine
Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors
Effect of the nootropic drug oxiracetam on field potentials of rat hippocampal slices
Anti-inflammatory properties of noopept
Noopept stimulates the expression of NGF and BDNF in rat hippocampus
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You just want studies in healthy humans?
Pharmacodynamics of piracetam and piracetam-like drugs.
EEG of healthy individuals after piracetam.
Piracetam prevents hypoxia in healthy individuals.
Piracetam effects on blood flow and vasodilation in normal individuals.
Piracetam attenuated decreases in vigilance in healthy individuals.
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Aniracetam prevents hypoxia in healthy individuals
Multiple dose aniracetam plasma pharmacodynamics in healthy volunteers.
Single dose pharmacodynamics in healthy Chinese males.
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Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers.
Acute doses of oxiracetam in scolpamine induced amnesia in healthy individuals.
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Pramiracetam's effects on scolpamine induced amnesia in healthy volunteers.
Pharmacokinetics of pramiracetam in healthy volunteers.
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Meteoadaptogenic properties of peptide (noopept) drugs in healthy volunteers.
Neuroprotective function of noopept.
Noopept prevents oxidative damage in normal individuals.
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Just because you have not researched very much, and do not know how these substances work, does not mean none of us do. How about you go over to Google Scholar and do some searching? Then you can come back and lecture me on misinformation.