Comment · Sat, June 22, 2013

Are there any effects of MAOI on Kratom alkaloids?

Original post in this thread

[deleted] · 10 points

Dear DrugNerds,
as I read about potential ways to enhance the effects of Kratom and its respective alkaloids, I stumbled upon various mentions of MAOIs (especially the very weak ones found in Grapefruit Juice (Naringenin and Bergamottin)) as possible substances.
Is there any scientific guess wether this could work? Since Mytragnin is indol-based, I don't see a way how a MAOI could affect its metabolism anyhow.
Thanks!

What they were answering

Pixielo · 1 points

For the inhibitor, it's hard to beat OTC cimetidine for being cheap, and easy to find!

u/MisterYouAreSoDumb

cimetidine

That inhibits CYP2D6 as well, which we don't want when using kratom. Perhaps for the MDMA supplement, but not the kratom.

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