Comment · Fri, June 21, 2013

Are there any effects of MAOI on Kratom alkaloids?

Original post in this thread

[deleted] · 10 points

Dear DrugNerds,
as I read about potential ways to enhance the effects of Kratom and its respective alkaloids, I stumbled upon various mentions of MAOIs (especially the very weak ones found in Grapefruit Juice (Naringenin and Bergamottin)) as possible substances.
Is there any scientific guess wether this could work? Since Mytragnin is indol-based, I don't see a way how a MAOI could affect its metabolism anyhow.
Thanks!

What they were answering

[deleted] · 1 points

[deleted]

u/MisterYouAreSoDumb

It definitely warrants more investigation. Perhaps it's the CYP2D6 induction leading to most of the effects, but there is a difference, for sure. I also notice kratom to not be as effective on days I take modafinil, which is a CYp3A4 inducer. Something is going on.

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