Comment · Thu, June 20, 2013
Are there any effects of MAOI on Kratom alkaloids?
Original post in this thread
[deleted] · 10 points
Dear DrugNerds,
as I read about potential ways to enhance the effects of Kratom and its respective alkaloids, I stumbled upon various mentions of MAOIs (especially the very weak ones found in Grapefruit Juice (Naringenin and Bergamottin)) as possible substances.
Is there any scientific guess wether this could work? Since Mytragnin is indol-based, I don't see a way how a MAOI could affect its metabolism anyhow.
Thanks!
What they were answering
[deleted] · 3 points
Naringenin is the aglycone of naringin, and the actual active substance after first digestion in the stomach, sorry that I got that mixed up.
After further reading, how did I even come up with MAOI, must have been somewhere in my head...
Do you know which kratom alkaloid compounds are affected exactly?
Are there any genetic factors involved, like a different amount/occurence of CYP3A4 in populations? Are there people that can not get the "grapefruit effect" with kratom?
Any personal experiences?
I did not notice much of a difference today, although almost 1l of pure white grapefruit juice was taken with a dose of maybe 4g...
u/MisterYouAreSoDumb
It seems that while CYP3A4 is responsible for metabolizing the active constituents, CYP2D6 is responsible for activating them. This means that ideally you want to inhibit CYP3A4 and induce CYP2D6. Many people have lower expression for the CYP2D6 enzyme. Perhaps you are have low CYP2D6. You can take black pepper with your grapefruit juice to induce CYP2D6, via the piperidine.
I have not dealved into the pharmacodynamics too much, so I am not sure of the specifics. However, I would think that it has to do with the mitragynine/hydroxymitragynine ratios.