Can we have a post for the beginners for understanding NMDA nootropic action?

Comment · Fri, March 15, 2013 · 2 pts

Haha, you said most of what I was going to say. Good job! I saw this post when it first came up, but I had food poisoning and my brain was not working. I'm glad you stepped up to give a great explanation!

Comment · Sat, March 16, 2013 · 3 pts

Yes, the traditional CILTEP stack is functioning on enhancing LTP from a different angle. However, NMDA function is key for LTP to occur. You can enhance the function of the AMPA, NMDA, and cAMP simultaneously. You just

Comment · Sat, March 16, 2013 · 3 pts

And if you are looking for an accessible novel modulator of the NMDA receptor, nefiracetam is a good one. It binds to the glycine site of the NMDA receptor like GLYX-13 does. We'll have to wait a bit to get GLYX-13 for a

Comment · Sat, March 16, 2013 · 1 pts

Most people use artichoke extract for cAMP, forskolin for PDE-4 inhibition, then something in increase dopamine like caffeine or PEA. Phenylpiracetam would be good because it will increase dopamine from the PEA structure

Comment · Sun, March 17, 2013 · 2 pts

Dopamine is needed for the whole CREP process to occur. I've never heard of UWA-101. It looks very interesting! It also bolsters my case for MDMA toxicity being caused by metabolites, since it has a much higher dopamine

Comment · Sun, March 17, 2013 · 2 pts

Nefiracetam would be a good one. Magnesium blocks the channel. It does not allosterically modulate the receptors themselves.

Comment · Sun, April 14, 2013 · 2 pts

You always want magnesium. It only blocks the channel until the cell reaches excitability, then it clears the channel. Most people are deficient in magnesium, so it's always good to supplement it.