Comment · Sun, April 14, 2013 · Ceretropic

Can we have a post for the beginners for understanding NMDA nootropic action?

Original post in this thread

[deleted] · 21 points

I'm new. AMPA receptors make a lot more sense than NMDA receptors when it comes to enhanced cognition, but they both seem crucial.

With NMDA receptors. Antagonists, agonists, and modulators all seem to have a complex role that I don't understand when it comes to cognition enhancement.

For instance Ketamine and PCP are an antagonistic yet so is Memantine and huperzine-A . Some cause Olney's Lesions and others are for Alzheimers.

Is there a NMDA explanation that is more straightforward out there?

Can somebody lay out NMDA for those in the dark like me?

What they were answering

[deleted] · 1 points

So what would happen if you take a NMDA (+) allosteric modulator AND something like magnesium L-threonate or mag-L-glycinate? Too much suppression, or even better, or....?

(I'm obviously still a little confused about the mechanisms here.)

u/MisterYouAreSoDumb · Ceretropic

You always want magnesium. It only blocks the channel until the cell reaches excitability, then it clears the channel. Most people are deficient in magnesium, so it's always good to supplement it.

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