Comment · Sun, March 17, 2013 · Ceretropic
Can we have a post for the beginners for understanding NMDA nootropic action?
Original post in this thread
[deleted] · 21 points
I'm new. AMPA receptors make a lot more sense than NMDA receptors when it comes to enhanced cognition, but they both seem crucial.
With NMDA receptors. Antagonists, agonists, and modulators all seem to have a complex role that I don't understand when it comes to cognition enhancement.
For instance Ketamine and PCP are an antagonistic yet so is Memantine and huperzine-A . Some cause Olney's Lesions and others are for Alzheimers.
Is there a NMDA explanation that is more straightforward out there?
Can somebody lay out NMDA for those in the dark like me?
What they were answering
[deleted] · 1 points
"Adding a positive allosteric modulator of the NMDA receptors along side..."
Which would be what exactly? Mag-L-Threonate? GLYX-13?
Are we not even there yet? (barring magnesium)
u/MisterYouAreSoDumb · Ceretropic
Nefiracetam would be a good one. Magnesium blocks the channel. It does not allosterically modulate the receptors themselves.