Comment · Fri, March 15, 2013 · Ceretropic

Can we have a post for the beginners for understanding NMDA nootropic action?

Original post in this thread

[deleted] · 21 points

I'm new. AMPA receptors make a lot more sense than NMDA receptors when it comes to enhanced cognition, but they both seem crucial.

With NMDA receptors. Antagonists, agonists, and modulators all seem to have a complex role that I don't understand when it comes to cognition enhancement.

For instance Ketamine and PCP are an antagonistic yet so is Memantine and huperzine-A . Some cause Olney's Lesions and others are for Alzheimers.

Is there a NMDA explanation that is more straightforward out there?

Can somebody lay out NMDA for those in the dark like me?

What they were answering

Cr15py · 3 points

I've heard a lot of praise for magnesium glycinate for being the most cost effective. Magnesium L-threonate is said to be the best for cognitive enhancement purposes.

u/MisterYouAreSoDumb · Ceretropic

Haha, you said most of what I was going to say. Good job! I saw this post when it first came up, but I had food poisoning and my brain was not working. I'm glad you stepped up to give a great explanation!

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