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Comment · Sat, March 16, 2013 · Ceretropic

Can we have a post for the beginners for understanding NMDA nootropic action?

Original post in this thread

[deleted] · 21 points

I'm new. AMPA receptors make a lot more sense than NMDA receptors when it comes to enhanced cognition, but they both seem crucial.

With NMDA receptors. Antagonists, agonists, and modulators all seem to have a complex role that I don't understand when it comes to cognition enhancement.

For instance Ketamine and PCP are an antagonistic yet so is Memantine and huperzine-A . Some cause Olney's Lesions and others are for Alzheimers.

Is there a NMDA explanation that is more straightforward out there?

Can somebody lay out NMDA for those in the dark like me?

What they were answering

[deleted] · 1 points

I was waiting for you to show up.

Kirby999 up at the top of the page on his first link showed NMDA function was mandatory for LTP.

What do you think this has to do with the CILTEP stack?

http://www.longecity.org/forum/topic/51732-chemically-induced-ltp/

It seems like they're going about LTP a different way than what Kirby999 was learning, right?

u/MisterYouAreSoDumb · Ceretropic

And if you are looking for an accessible novel modulator of the NMDA receptor, nefiracetam is a good one. It binds to the glycine site of the NMDA receptor like GLYX-13 does. We'll have to wait a bit to get GLYX-13 for a reasonable price.

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