Original post · Sat, December 1, 2012 · Ceretropic

Hypomanic modafinil rebound

u/MisterYouAreSoDumb · Ceretropic

I had a very interesting interaction a couple days ago. I had been taking 75mg D-modafinil every day for 5 days, while ceasing my caffeine supplementation. I got back home from Thanksgiving in Colorado, and decided to drop the modafinil and return to my normal stack.

In the morning I took:

200mg caffeine

10mg noopept

500mg bacopa

120mg ginkgo

500mg ALCAR

150mg Na-R-ALA

200mg magnesium glycinate

200mg EGCG

500mg quercetin

sublingual B complex

1,600mg piracetam

_________________________________________________

Well this resulted in a first class ticket to hypomaniaville! It must have been a rebound effect from adding caffeine back in with the residual effects from the modafinil. I am pretty certain it has something do do with modafinil's induction of certain CYP450 enzymes. It was not unpleasant, and I was fully aware of what was going on. In fact, it was extremely enjoyable. I had dopamine/serotonin tingles shooting through my head all day long. It literally felt like I had taken MDMA. The next day I kept my stack exactly the same, but it did not lead to the same result. It worked, but more from a focused standpoint.

Anybody else have a similar effect from modafinil's induction of enzymes?

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