Comment · Thu, November 29, 2012
Magnesium L-Threonate's MoA
Original post in this thread
Arkanj3l · 3 points
Jonathan Toomim dropped this tight rap about MLT and how it potentially worked as a cognitive enhancer. It might not have anything to do with L-Threonate per se and just the bioavailability; one may expect similar effects from less bioavailable substances dosed en masse?
(Taking out some linear programming chart or something would figure out if supping with MLT versus some other type of mag would be more effective. Anyway, enjoy.)
>Yes, it still seems high. Magnesium L-threonate has a molecular weight
of 284.5, of which 24.3 is Mg, so it's only 560 mg of elemental
magnesium. Still, that sounds like a lot, especially since it's
supposed to have higher bioavailability than other forms of Mg. The
NIH recommended maximum for Mg is 350 mg/day (http://en.wikipedia.org/wiki/Magnesium_citrate#Dosage
).
I'm curious whether the innovation in the Slutsky et al study was just
the high dosage (combined with the higher bioavailability), rather
than the use of the L-threonate salt itself. I couldn't find a mention
of the dosage they used with the magnesium citrate and
I took a look through the Slutsky e…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
It is worth noting that your NMDA receptors will not open even in the presence of glutamate, unless glycine is also bound to the receptor. Mg++ blocks the channel from opening, even if glutamate and glycine are both bound to their respective binding sites, unless the voltage rises above -40mV. So like you said, Mg++ blocks the channel from passing Ca++ and K+ unless it's in an excited state. I personally like taking magnesium glycinate because of this. It's highly bioavailable, and delivers both Mg++ and glycine to your brain. Then one can supplement an appropriate NMDA receptor positive/negative allosteric modulator, like piracetam and/or noopept, to increase excitability of the ion channel, while maintaining voltage-dependent control of it's closure. This will provide optimal excitability of your ion channels, while still protecting against excitotoxicity.
I take fully chelated magnesium glycinate/lysinate. I know L-theonate has been shown to decrease DKK1 expression, but it's elemental magnesium amounts are so low compared to the pill size! Not to mention the price difference. Also, my supplement delivers glycine to the brain along with the Mg++, which is the second half of NMDA receptor activation that most people overlook.
So in my current opinion, magnesium glycinate/lysinate makes more sense as a supplement than magnesium L-theonate, save for the benefit of lower DKK1 expression. Thoughts?