Comment · Thu, December 20, 2012
Which substance, in your opinion, is the hardest to remember what happened afterwards? Also, what is your best blackout story?
Original post in this thread
CalfAssed · 64 points
After a pretty hefty dose of shrooms and mephedrone I found bits of scrumpled paper with drawings that I can't for the life of me remember when or why I did them.
Best blackout story: Age 14 I was on a mountain drinking white cider and Famous Grouse mixed with cheap energy drinks. Everything was a fog and I remember waking in a ditch with about 10 kids on bikes shouting shit at me and throwing stones before transcending into unconsciousness and coming around again in somebody's garden vomiting over a girl I've never met.
What they were answering
[deleted] · 1 points
What NMDA excitotoxicity?
A lot of people take 2mg lorazepam, 20mg Dexedrine and cetirizine (a 2nd gen antihistamine that wouldn't cause drowsiness in 90% of the population) each and every day.
u/MisterYouAreSoDumb
Your NMDA receptors control the opening and closing of your ion channels that allow calcium to influx into a neuron. This is how your body sends cascading electrical signals through the brain. Amphetamine increases extracellular glutamate, which is the substance that binds to the NMDA receptor and opens the channel. This can allow too high of concentrations of calcium to enter the neuron, reducing effectiveness of your ion channel, or even damaging the neuron itself if the concentrations get too high. That is why I take magnesium, because it is a voltage dependent block of the channel itself. However, if the membranes electrical potential rises above -60mV, then it clears the channel and allows for normal operation. This means that it protects your neurons for excitotoxicity, but still allows them to operate normally.