Comment · Thu, November 22, 2012
MDMA Neurotoxicity Part 1 Metabolites)
Original post in this thread
MisterYouAreSoDumb · 129 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
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First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
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MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
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What they were answering
Sanwi · 1 points
Thanks! How do you deal with the crash? Weed?
u/MisterYouAreSoDumb
There is no crash. NONE! If you supplement the way I do, all you have is a two week long afterglow. Preventing the creation of the toxic metabolites, in combination with taking strong antioxidants for anything that does get created, prevents all bad side effects from MDMA use. Also, inhibiting CYP3A4 prevents the creation of the ring-hydroxylated metabolite 2,4,5-trihydroxyamphetamine (THA), which is the primary substance responsible for lowering your tryptophan hydroxylase. This means that your serotonin stores will replenish at normal rates! Perhaps due to the complexity of what I am saying, people don't realize the implications of my findings. I can take even up to 300mg (Not suggesting it though) of MDMA in a night, get a good nights sleep, wake up feeling like a million dollars, and have a 2 week afterglow, with no bad side effects. I've done it many times now. My supplementation works, and now I understand why!