Comment · Sat, November 24, 2012
MDMA Neurotoxicity Part 1 Metabolites)
Original post in this thread
MisterYouAreSoDumb · 129 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
_________________________________________________
First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
________________________________________________
MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
This is…
What they were answering
slyman928 · 2 points
i'm in the US and it's a venue for shows that i'm talking about not a club btw. clubs and whatnot usually don't pat you down
u/MisterYouAreSoDumb
You mean like festivals? I will confess that I have not been to one in the US yet. I've been to some in Europe. Those I just have a female that is with me put a care package in her bra. Still though, for vitamin supplements they have no right to take them from you. Tell them you have a medical condition, and you need them to prevent it. If they give you issues, tell them to bring an officer over to discuss it. Just make sure that someone else has the illegal stuff when you do, and that all you have is vitamins.